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Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment

https://repo.qst.go.jp/records/69441
https://repo.qst.go.jp/records/69441
b6f8a51d-1ca7-4418-9ce2-69fcc1219eb4
Item type 会議発表用資料 / Presentation(1)
公開日 2008-09-02
タイトル
タイトル Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Noguchi, Miho

× Noguchi, Miho

WEKO 681470

Noguchi, Miho

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Hirayama, Ryoichi

× Hirayama, Ryoichi

WEKO 681471

Hirayama, Ryoichi

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Druzhinin, Sergey

× Druzhinin, Sergey

WEKO 681472

Druzhinin, Sergey

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Okayasu, Ryuichi

× Okayasu, Ryuichi

WEKO 681473

Okayasu, Ryuichi

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野口 実穂

× 野口 実穂

WEKO 681474

en 野口 実穂

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平山 亮一

× 平山 亮一

WEKO 681475

en 平山 亮一

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Druzhinin Sergey

× Druzhinin Sergey

WEKO 681476

en Druzhinin Sergey

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岡安 隆一

× 岡安 隆一

WEKO 681477

en 岡安 隆一

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抄録
内容記述タイプ Abstract
内容記述 Herbimycin A (HA), as in Geldanamycin, binds to conserved pockets of heat shock protein 90 (Hsp90) and inhibits its chaperone functions. Hsp90 plays an important role in cancer cell growth and survival through maintaining stability of several proteins by its chaperones activity. It is known that some of the proteins associated with radiation responses are functionally stabilized by Hsp90. In this study, we investigated the effect of HA on radiosensitivity in human cancer cells and the mechanism related to the sensitization. For mechanistic insight of sensitization, we examined repair of DNA double strand breaks (DSBs) in irradiated human cancer cells pre-treated with HA; DSBs are thought to be the critical target for radiation-induced cell death. Cellular radiosensitivity was determined by clonogenic assay, and the DSB rejoining kinetics was examined by constant field gel electrophoresis. SQ-5, a lung squamous carcinoma cell line, showed synergistic increase in radiosensitivity when cells were pre-treated with HA. In addition, HA significantly inhibited repair of radiation induced DSBs. The results suggest that the combination of HA and ionizing radiation may be a useful therapeutic strategy in treating certain cancer cells.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 The 2nd Asia-Pacific Symposium on Radiation Chemistry (APSRC-2008)
発表年月日
日付 2008-09-01
日付タイプ Issued
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