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マウスモデルにおける重粒子照射誘導ストレス反応遺伝子群の発現変化
https://repo.qst.go.jp/records/69263
https://repo.qst.go.jp/records/692632cb2d520-d201-4bf6-997f-2bc04505a989
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-01-09 | |||||
| タイトル | ||||||
| タイトル | マウスモデルにおける重粒子照射誘導ストレス反応遺伝子群の発現変化 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
今留, 香織
× 今留, 香織× 岩川, 眞由美× 野尻, 和典× 田巻, 倫明× 酒井, 美奈子× 中渡, 美也子× 盛武, 敬× 柳澤, 充× 中村, 悦子× 辻井, 博彦× 今井, 高志× 今留 香織× 岩川 眞由美× 野尻 和典× 田巻 倫明× 酒井 美奈子× 中渡 美也子× 盛武 敬× 柳澤 充× 辻井 博彦× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In vivo biological effects induced by carbon-ion (C-ion) are still not fully understood. We examined gene expression changes for six mouse leg tumors of C3H/HeNrs mice using 44K oligo-microarrays at 6 hours (h), 1 day, and 3 days after C-ion irradiation with a single dose of 30 Gy. Gamma rays of 30 Gy and 50 Gy were used as a reference beam. In all six tumors, C-ion significantly changed the expression amounts of several tens of genes, including Cdkn1a, Ccng1, Ercc5, Mgmt, Cd80, and Polk at 6 h and 1 day, and Casp4, Tnfrsf6, Ikbke, Ifi202b, Fdps, and Ecm1 at 3 days. Expression changes of stress-responsive genes and cell communication-related genes lasted until 3 days. Expression changes of these genes in gamma-ray-treated samples were mostly similar or less than with C-ion, with large intertumor variance, while several genes, including Ikbke and Saa3, responded quite differentially from those irradiated by C-ions. Sequential immunohistochemical analysis of AurkA, Cdc20, and Cdkn1a revealed cell cycle/division arrest with mitotic catastrophe. Prolonged upregulation of stress-marker proteins and downregulation of cell-cycle promotion molecules provided evidence for the efficacy of this modality for local tumors. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2007-12-15 | |||||
| 日付タイプ | Issued | |||||
