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Radical-Scavenging Rates of Biosynthetic Precursors of Vitamin E and Their Acyclic Analogues
https://repo.qst.go.jp/records/69222
https://repo.qst.go.jp/records/6922287e87239-797c-49a3-8d7d-b9415e0552f4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-07 | |||||
| タイトル | ||||||
| タイトル | Radical-Scavenging Rates of Biosynthetic Precursors of Vitamin E and Their Acyclic Analogues | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Uto, Yoshihiro× Ohkubo, Kei× Nagasawa, Hideko× Hori, Hitoshi× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× et.al× 中西 郁夫× 小澤 俊彦× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is known that 2-methyl-6-phytylhydroquinone (2-MePHQ) and 2,3-dimethyl-6-phytylhydroquinone (2,3-Me2PHQ) are formed as precursors in the biosynthetic process of vitamin E. However, very little is known about the antioxidative activity of these vitamin E precursors. Thus, we examined the radical-scavenging reactions of 2-MePHQ, 2,3-Me2PHQ, and their synthetic analogues, 2,5-dimethyl-6-phytylhydroquinone (2,5-Me2PHQ) and 2,3,5-trimethyl-6- phytylhydroquinone (2,3,5-Me3PHQ). 2,2-Diphenyl-1-picrylhydrazul radical (DPPH) was efficiently scavenged by these four hydroquinones in deaerated ethanol (EtOH) at 298 K. From the decay of the absorbance at 516 nm due to DPPH, the second-order rate constants (kobs) for DPPH-scavenging reactions by the hydroquinones were determined as 280 (2-MePHQ), 390 (2,3-Me2PHQ), 280 (2,5-Me2PHQ), and 410 M-1 s-1 (2,3,5-Me3PHQ) in deaerated EtOH at 298 K. 2,3,5-Me3PHQ and 2,3-Me2PHQ, which have a methyl group at the C-3 position, showed a stronger DPPH-scavenging activity than alpha-tocopherol (kobs = 370 M-1 s-1). The detailed mechanism of the DPPH-scavenging reactions by the hydroquinones will also be discussed based on the kinetic and theoretical results obtained in this study. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Conference on Food Factors for Health Promotion (ICoFF2007) | |||||
| 発表年月日 | ||||||
| 日付 | 2007-12-01 | |||||
| 日付タイプ | Issued | |||||
