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Detecting Free Radical Reactions Induced by Low Linear-Energy-Transfer Irradiation in an Aqueous Solution using a Nitroxyl Radical
https://repo.qst.go.jp/records/69187
https://repo.qst.go.jp/records/69187bea3edaf-9d4b-47ca-b102-1fb7fbe6cc67
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-11-22 | |||||
| タイトル | ||||||
| タイトル | Detecting Free Radical Reactions Induced by Low Linear-Energy-Transfer Irradiation in an Aqueous Solution using a Nitroxyl Radical | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Kenichiro
× Matsumoto, Kenichiro× et.al× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Stability and reactivity of reaction mixtures containing 0.1 mM of a nitroxyl free radical probe, i.e. 4-hydroxyl-TEMPO (TEMPOL) or 3-carbamoyl-PROXYL (CmP), and 1 M of a hydrogen donor, i.e. GSH, NADH, or NADPH were tested. X-band EPR measurements of several reaction mixtures were performed to find a suitable preparation to detect free radical reactions produced by low linear-energy-transfer (LET) irradiation at relatively low dose (< 16 Gy). The EPR signal intensity of nitroxyl radicals were decreased by X-ray (Eeff = 80 keV) irradiation when a hydrogen donor was coexisting in the reaction mixture. The combination of TEMPOL and GSH was most preferable among other preparation tested in this study, because of the sensitivity and irreversible reaction. This combination can also be applied to test effects of other radiation sources, i.e. beta-, and gamma-ray. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Society for Free Radical Biology and Medicine 14th Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2007-11-18 | |||||
| 日付タイプ | Issued | |||||
