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Hyper diploid lymphocytes due to aging in a woman living in the high level natural radiation area in Ramsar, Iran.
https://repo.qst.go.jp/records/69064
https://repo.qst.go.jp/records/69064c9175c1c-65bf-4514-bfd4-241850960766
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-27 | |||||
| タイトル | ||||||
| タイトル | Hyper diploid lymphocytes due to aging in a woman living in the high level natural radiation area in Ramsar, Iran. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Minamihisamatsu, Masako
× Minamihisamatsu, Masako× Furukawa, Akira× Kanda, Reiko× Sugahara, Tsutomu× Hayata, Isamu× et.al× 南久松 眞子× 古川 章× 神田 玲子× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chromosome aberrations to be induced by radiation usually take the form of structural aberrations. In our study one woman in a high background radiation area in Ramsar, Iran, had cells with additional chromosomes in peripheral lymphocytes. She was a 62-year-old housewife without any genetic abnormality. She married at the age of 20 years old, and started to live in the house where thereafter she was exposed to the high level of natural radiation. The exposed dose was measured 3 times using a pocket dose meter (Aloka PDM-101) put on her body for 24 hours. The measured doses were 80.4 muSv, 96.6 muSv and 136.9 muSv, respectively. The accumulated exposed dose after her marriage was estimated to be 1.64 Sv that was calculated with the average measured values of 104.6 muSv/day. The frequency of dicentrics plus centric rings (markers of radiation exposure) in 2038 cells analyzed was 12, which is about 6 times higher than normal frequency. Thus the effect of radiation is clearly shown in the lymphocytes. There were totally 18 hyper diploid cells: one cell had 7 additional C group chromosomes; one cell had two additional C; 13 cells had one additional C; one cell had one additional A; one cell had one additional D; and one cell had one additional E. Most of the extra chromosomes showed acentric like morphology of the premature centromere separation. FISH chromosome painting performed in her different chromosome slides revealed that the origin of the additional C was X chromosome. There were cells with 2 X-bodies indicating that they were inactive X. It seems these unusual X chromosomes had ability to replicate. This replication was associated with non-disjunction leading to aneuploid cells. The lymphocytes with additional X chromosome(s) were found in an age matched woman in control also who had cells with additional C in the similar frequency. The finding of 7 additional C in a lymphocyte in the normal blood is extremely unusual. It is assumed that the induction of the aneuploid cells might be the result of aging rather than the effect of radiation. The aneuploid cells in the lymphocyte will be discussed in terms of aging and radiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
