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Study on radiation-induced adaptive response in fetal mice.
https://repo.qst.go.jp/records/69061
https://repo.qst.go.jp/records/69061c1edde73-f7a0-4f9c-bd4f-cefcf06c5d49
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-25 | |||||
| タイトル | ||||||
| タイトル | Study on radiation-induced adaptive response in fetal mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Shang, Yi× Vares, Guillaume× Morimoto, Yasuko× Nakajima, Tetsuo× Nenoi, Mitsuru× Hayata, Isamu× 王 冰× 田中 薫× 尚 奕× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 森本 泰子× 中島 徹夫× 根井 充× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A radiation-induced adaptive response, which was judged as reduction of both fetal death and digital malformation, was demonstrated in fetal mice by priming low-dose radiation on E11 prior to a high-dose irradiation on E12. Suppression of the digital defects was correlated to the inhibition of radiation-induced apoptosis. The priming dose was mouse strain-related. Both Trp53 alleles were essential for induction of the adaptive response. Furthermore, existence of the dose-rate effect was verified for delivery of the priming dose. There was a high postnatal mortality in the offspring that survived from prenatal death. Postnatal retardation, alteration in adult behavior, and life span shortening were observed in the survivals. In addition, a significantly increased radiosensitivity to the killing effect was also observed in the postnatal survivals. These results indicate that radiation-induced adaptive response in fetal mice is due to a complex interplay between dose, dose rate and animal factors such as the strain, developmental stage, and gene background. Though the priming dose could rescue some mice from high dose irradiation, the survivals are not healthy as alterations in development, behavior and radiosensitivity were observed. This work was supported in part by the Budget for New Nuclear Crossover Research from the Ministry of education, Culture, Sports, Sciences and Technology, Japan. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
