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Promoter methylation of Slc family genes in rat mammary tumors induced by gamma rays or carbon ions
https://repo.qst.go.jp/records/69043
https://repo.qst.go.jp/records/6904364aeaa21-acba-4a02-8e1c-b7c4267b46a8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-19 | |||||
| タイトル | ||||||
| タイトル | Promoter methylation of Slc family genes in rat mammary tumors induced by gamma rays or carbon ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishimura, Mayumi
× Nishimura, Mayumi× Imaoka, Tatsuhiko× Kakinuma, Shizuko× Yamaguchi, Yu× Ohmachi, Yasushi× Yamashita, Satoshi× Ushijima, Toshikazu× Shimada, Yoshiya× 西村 まゆみ× 今岡 達彦× 柿沼 志津子× 山口 悠× 大町 康× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aberrant methylation of CpG islands, which are CpG dinucleotide rich areas located in the promoter region of many genes, serves as a mechanism for inactivation of tumor suppressor genes in many cancers. It is reported that lung tumors induced by plutonium and, to a lesser extent, X-rays showed higher frequency of estrogen receptor (ER) promoter methylation than those induced by NNK, suggesting a close link between radiation exposure and promoter methylation. Recently, Slc family is suspected as a new tumor suppressor gene in human colon and breast cancers. In the present study, we examined the status of expression and promoter methylation of Slc family genes in radiation (gamma-rays or carbon ions) -induced rat mammary tumors comparing them with spontaneous and chemically (MNU or PhIP) induced ones. We found up-regulation of Slc7a1, 7a5(Lat1) and 16a13 and down-regulation of Slc1a5, 7a8(Lat2), 7a10, 28a2 and 28a3, suggesting an unbalance of transport of neutral amino acids, purine and pyrimidine. Promoter of Slc7a10 was found heavily methylated in chemically induced tumors, but, unexpectedly, less methylated in spontaneous and radiation-induced ones. It is suggested that promoter methylation of Slc7a10 is dependent on the carcinogens in rat mammary tumors. Other Slc genes, which contain CpG islands in their promoter, are now under investigation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
