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The Maximal Protection by DMSO of Mammalian Cells Exposed to Very High LET Radiations
https://repo.qst.go.jp/records/69042
https://repo.qst.go.jp/records/690429e725163-ca14-4c17-a51b-270b1e41c2a7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-19 | |||||
| タイトル | ||||||
| タイトル | The Maximal Protection by DMSO of Mammalian Cells Exposed to Very High LET Radiations | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Ito, Atsushi× Furusawa, Yoshiya× Ando, Koichi× Tomita, Masanori× Tsukada, Teruyo× Izumi, Masako× Yatagai, Fumio× Okayasu, Ryuichi× 平山 亮一× 伊藤 敦× 古澤 佳也× 安藤 興一× 谷田貝 文夫× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To understand indirect action for high linear energy transfer (LET), we examined the radioprotection effects of dimethylsulfoxide (DMSO) on the cell killing for cells irradiated with very high LET heavy ions. Exponentially growing Chinese hamster V79 cells were exposed to low- and high-LET radiations. We estimated that a maximal protectable fraction from a regression lines in the reciprocal plots degree of radical scavenger against the concentration from the cell survival curves. The contribution of indirect action decreased with increasing LET, but remained at the very high LET region. The contribution of indirect action in the cell killing were 52, 39 and 32% at LET of 797, 1298 and 2106 keV/mm, respectively. When cell survival curves were analyzed by the linear-quadratic equation, dependence of the DMSO concentration on the survival curve parameters were found. The quadratic (b) term depends on DMSO concentration in X-rays, and the linear (a) term depends on that in the very high LET radiation. The results suggest that an indirect action to cell killing results from a double-event mechanism in X-rays, and from a single-event mechanism in the very high LET radiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th international Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
