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Effect of simulataneous exposure of X-rays and N-ethyl-N-nitrosourea on lymphomagenesis in B6C3F1 mice
https://repo.qst.go.jp/records/69040
https://repo.qst.go.jp/records/6904037c0ef7c-e4d1-4b6a-b51e-30e89e9d09cb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-18 | |||||
| タイトル | ||||||
| タイトル | Effect of simulataneous exposure of X-rays and N-ethyl-N-nitrosourea on lymphomagenesis in B6C3F1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Amasaki, Yoshiko
× Amasaki, Yoshiko× Kakinuma, Shizuko× Yamauchi, Kazumi× Nishimura, Mayumi× Imaoka, Tatsuhiko× Hirano, Shinobu× Kobayashi, Yoshiro× Shimada, Yoshiya× 甘崎 佳子× 柿沼 志津子× 山内 一己× 西村 まゆみ× 今岡 達彦× 坂入 しのぶ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation carcinogenesis in human is considered as a result of the combined effect of radiation and environment factors. We previously showed that the combined effect on the induction of thymic lymphoma (TL) after exposure to X-rays and N-ethyl-N-nitrosourea (ENU) was dependent upon dose of carcinogen and treatment order. Considering our real life, the simultaneous exposure of radiation and chemical carcinogen is the most common case. The aim of this study is to elucidate the mode and mechanism of the combined effect on TL development after simultaneous exposure of X-rays and ENU. Four-week-old female B6C3F1 mice were exposed to X-rays (0.2 to 1.0 Gy per week) for 4 consecutive weeks, and simultaneously treated with ENU (0, 50, 100, 200 ppm) in drinking water. Combination of low dose of X-rays (0.2 and 0.4Gy x4) and ENU (50 ppm) did not induce TL. However, in combination of higher dose of X-rays (0.8 and 1.0 Gy x4) and ENU (100 and 200 ppm), the TL development was synergistically enhanced. Molecular analysis demonstrated that the frequency of point mutations of Ikaros in the TL after simultaneous exposure was increased (43%) compared with that after single exposure of X-rays (20%) or ENU (16%). TL induced by simultaneous exposure harbored not only mutations, which were identical with those found in TL by single exposure of ENU, but also new type of mutation such as G to T. It is concluded that synergistic effect of simultaneous exposure is ascribed, at least in part,to the increased frequency of point mutation of Ikaros. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
