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Radioprotective effect of zinc yeast is p53 dependent to human lymphoblastoid cells
https://repo.qst.go.jp/records/69037
https://repo.qst.go.jp/records/69037e2cec462-0c31-4cdb-800e-3b27cfd00bd5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-18 | |||||
| タイトル | ||||||
| タイトル | Radioprotective effect of zinc yeast is p53 dependent to human lymphoblastoid cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujii, Yoshihiro
× Fujii, Yoshihiro× Kato, Takamitsu× Fujimori, Akira× Okayasu, Ryuichi× 藤井 義大× 加藤 宝光× 藤森 亮× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It was shown that the administration of zinc-containing yeast (zinc-yeast) to the abdominal cavity significantly increased the survival of mice irradiated with 7.5 Gy X-rays (LD50/30 assay result). In order to elucidate the molecular mechanism of this radio-protection effect, we examined TK6 (p53 wild type) and WTK1 (p53 mutant) lymphoblast cell lines exposed to 0.1mg/ml zinc-yeast. In TK6 cells, the cell growth was impaired after administration of zinc-yeast and the cells seem to accumulate at S/G2 phase in the cell cycle. On the other hand, in WTK1 cells, no effect on cell growth was observed. Furthermore, we measured the occurrence of apoptosis in X-irradiated cells (10 Gy) treated with zinc-yeast post-irradiation. In TK6 cells, a significant reduction in apoptosis was observed with the combined treatment, while there was no clear difference observed in WTK1 cells under the same treatment. These data indicate that the radio-protective effect induced by zinc-yeast might be affected by the p53 status of irradiated cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
