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High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations

https://repo.qst.go.jp/records/69020
https://repo.qst.go.jp/records/69020
40b5ff45-feb6-4b03-941a-89b4d78bd320
Item type 会議発表用資料 / Presentation(1)
公開日 2007-07-17
タイトル
タイトル High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Imaoka, Tatsuhiko

× Imaoka, Tatsuhiko

WEKO 677371

Imaoka, Tatsuhiko

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 677372

Nishimura, Mayumi

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Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 677373

Kakinuma, Shizuko

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Hatano, Yukiko

× Hatano, Yukiko

WEKO 677374

Hatano, Yukiko

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Ohmachi, Yasushi

× Ohmachi, Yasushi

WEKO 677375

Ohmachi, Yasushi

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Yoshinaga, Shinji

× Yoshinaga, Shinji

WEKO 677376

Yoshinaga, Shinji

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Kawano, Akihiro

× Kawano, Akihiro

WEKO 677377

Kawano, Akihiro

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Maekawa, Akihiko

× Maekawa, Akihiko

WEKO 677378

Maekawa, Akihiko

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 677379

Shimada, Yoshiya

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今岡 達彦

× 今岡 達彦

WEKO 677380

en 今岡 達彦

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西村 まゆみ

× 西村 まゆみ

WEKO 677381

en 西村 まゆみ

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柿沼 志津子

× 柿沼 志津子

WEKO 677382

en 柿沼 志津子

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西村 由希子

× 西村 由希子

WEKO 677383

en 西村 由希子

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大町 康

× 大町 康

WEKO 677384

en 大町 康

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吉永 信治

× 吉永 信治

WEKO 677385

en 吉永 信治

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河野 明広

× 河野 明広

WEKO 677386

en 河野 明広

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島田 義也

× 島田 義也

WEKO 677387

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 Purpose: The high relative biologic effectiveness (RBE) of high linear energy transfer (LET) heavy-ion radiation has enabled powerful radiotherapy. The potential risk for later onset of secondary cancers, however, has not been adequately studied. We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model.
Materials and Methods: Seven- to eight-week-old rats (ACI, F344, Wistar and Sprague-Dawley) were observed until one year of age following irradiation (0.05–2 Gy) with either 290 MeV/u carbon ions with a spread-out Bragg peak (LET 40–90 keV/um) generated from the HIMAC synchrotron or 137Cs gamma-rays.
Results: Carbon ions significantly induced mammary carcinomas in Sprague-Dawley rats but less so in other strains. The dose-effect relationship for carcinoma incidence in Sprague-Dawley rats was concave downward, providing an RBE of 2 at a typical therapeutic dose per fraction, whereas ~10 should be considered for radiation protection at low doses. Immunohistochemically, 14 of 18 carcinomas were positive for estrogen receptor alpha. All carcinomas examined were free of common H-ras and Tp53 mutations. Importantly, lung metastasis (15%) was characteristic of carbon ion–irradiated rats.
Conclusions: We found clear genetic variability in susceptibility to carbon ion–induced mammary carcinomas. The high RBE for carbon ion radiation further supports the importance of precise dose localization in radiotherapy. Common point mutations in H-ras and Tp53 were not involved in carbon ion induction of rat mammary carcinomas.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 13th International Congress of Radiation Research
発表年月日
日付 2007-07-12
日付タイプ Issued
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