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Second cancers after uterine cervical cancer treated with radiation therapy.
https://repo.qst.go.jp/records/68792
https://repo.qst.go.jp/records/687923abbaef3-6157-4882-8bee-03a6027746f9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-11-24 | |||||
| タイトル | ||||||
| タイトル | Second cancers after uterine cervical cancer treated with radiation therapy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohno, Tatsuya
× Ohno, Tatsuya× Kato, Shingo× 大野 達也× 加藤 眞吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Second cancers after uterine cervical cancer treated with radiation therapy. \nBackground: Characterization of second cancer risk after radiation therapy is important in terms of patient management and enabling clinicians to choose the optimal treatment. Methods: We analyzed 2167 patients who had been treated with radiation therapy for uterine cervical cancer between 1961 and 1986. Relative risks (RRs) of second cancer were calculated by using the disease expectancy table provided by the Center for Adult Disease in Osaka. Results: The total number of person-years follow-up was 25771 and 60 patients were lost to follow-up. Two hundred and three patients developed second cancer after radiation therapy, which represents a significant increase in risk compared with a comparable normal population (RR=1.19, 95%CI=1.03-1.37). The estimated cumulative probability for development of a second cancer was 10.9% at 15 yeas and 19.8% at 25 years. The risk was significantly elevated for uterine corpus (RR=6.6, 95%CI=3.10-13.53), lung (RR=1.65, 95%CI=1.07-2.47), and leukemia (RR=3.11, 95%CI=1.35-6.88). Of the 1364 patients who survived more or equal 5 years, 39 developed second cancer in the irradiated field. The estimated cumulative probability for development of a second cancer was 2.38% at 15 yeas and 4.77% at 25 years. In patients who developed second cancer in the irradiated field, the 5-year overall survival rate was 11.2% and the median survival time was 6 months, indicating the poor prognosis. Conclusions: Significantly increased risk of second cancers after radiation therapy for cervical cancer was observed and the cumulative probability of developing second cancers has increased with longer follow-up. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 41st Annual Meeting of the American Society of Clinical Oncology | |||||
| 発表年月日 | ||||||
| 日付 | 2005-05-17 | |||||
| 日付タイプ | Issued | |||||
