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tracking a connection betweeen the formation and disappearance of gamma-h2AX foci in nulei and the prematurely condensed chromosomes of G0 human fibroblasts after gamma-irradiation.
https://repo.qst.go.jp/records/68771
https://repo.qst.go.jp/records/6877134dbebc9-a681-4e3f-98fd-9e3b6007fe1c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-11-15 | |||||
| タイトル | ||||||
| タイトル | tracking a connection betweeen the formation and disappearance of gamma-h2AX foci in nulei and the prematurely condensed chromosomes of G0 human fibroblasts after gamma-irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Takamitsu
× Kato, Takamitsu× Okayasu, Ryuichi× S., Bedford Joel× 加藤 宝光× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The time courses of the development and disappearance of gamma-H2AX foci after irradiation were measured in the nuclei of non cycling G0 human fibroblasts and in the same cells after induction of premature chromosome condensation (PCC). The purpose was to investigate possible connections between the rejoining and mis-rejoining of DNA (Double Strand Breaks) DSBs and the early formation of chromosome aberrations. For gamma-H2AX foci assayed in G0 nuclei after irradiation of G0 human fibroblasts, a maximum of about 30 foci per cell was observed after 1Gy, in agreement with estimate of the number of DNA DSBs expected for this dose. After 3Gy, the number of excess PCC fragments were about 18, the number of gamma-H2AX foci on PCC were about 90. After rapid decrease of foci number, the number of foci were always about twice the numbers of excess PCC fragments 3 hours after irradiation. gamma-H2AX foci in the prematurely condensed chromosomes were often seen at the broken ends of PCC fragments, and instances were also seen of gamma-H2AX foci at the junction point of translocations. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 53rd radiaiton research society meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2006-11-09 | |||||
| 日付タイプ | Issued | |||||
