WEKO3
アイテム
The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male
https://repo.qst.go.jp/records/68703
https://repo.qst.go.jp/records/68703b6ffd870-0418-4f17-aba6-0b682bae10f0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-10-02 | |||||
| タイトル | ||||||
| タイトル | The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Wakamatsu, Kazumasa× Ito, Shosuke× 廣部 知久 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The murine recessive yellow (Mc1re) is a loss-of-function mutation in the receptor for alpha-melanocyte-stimulating hormone (MSH), melanocortin receptor 1 (MC1R), and produces yellow coats by inducing pheomelanin synthesis in hair follicular melanocytes. However, it is not known whether Mc1re mutation affects pheomelanin synthesis in other skin sites. The eumelanin contents in the epidermis and dermis of newborn wild-type (Mc1r+/Mc1r+) mice (0.5, 3.5, 5.5 and 7.5 days) were much greater than those of mutant (Mc1re/Mc1re) mice, whereas the pheomelanin contents in the epidermis and dermis of mutant mice were much greater than those of wild-type mice. No sex differences in the contents of eumelanin and pheomalanin in the epidermis and dermis both in mutant and wild-type mice were observed. The eumelanin contents in mutant hairs (5-week-old) was much smaller than in wild-type hairs, whereas the pheomelanin contents in mutant hairs was much greater than in wild-type hairs. However, the eumelanin and pheomelanin contents in mutant female hairs were greater than in male. These sex differences were not observed in wild-type mice. These results suggest that the Mc1re gene stimulates pheomelanin synthesis in the epidermis, dermis and hair follicles. In addition, Mc1re gene may affect eumelanin and pheomelanin contents in hairs by influencing through sex-related mechanisms. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th meeting of the European Society for Pigment Cell Research | |||||
| 発表年月日 | ||||||
| 日付 | 2006-09-27 | |||||
| 日付タイプ | Issued | |||||
