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Improving contrast of iron oxide based cell labeling with manganese-enhanced MRI
https://repo.qst.go.jp/records/68624
https://repo.qst.go.jp/records/68624de2fcb4e-b8cd-47d5-93c8-655f89888cba
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-08-15 | |||||
| タイトル | ||||||
| タイトル | Improving contrast of iron oxide based cell labeling with manganese-enhanced MRI | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Aoki, Ichio
× Aoki, Ichio× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction : Recently, negative MR contrast induced by iron oxide particles gaining widespread use for imaging cellmigration in vivo. Iron oxide as a negative contrast agent has excellent "sensitivity" due to the large effect they have on T2 relaxation time and large susceptibility effects on T2 weighted MRI. Indeed, even detection of single micron sizediron oxide particles has been demonstrated (Shapiro EM,PNAS 27;101(30):10901-6, 2004).Aithought negative contrast agent is usuful for organs which have homogeneous positive background such as liver and brain, it is difficult to distinguish iron oxide contrast agent in areas of inherently low background signal,such as abdominal organs and cavities, or areas of high susceptibility caused by air or local magnetic field inhomogeneity. The purpose of this study is to use manganese-enhanced MRI(memri) to inprove SNR and contrast in tissuse prior to administration of iron-oxide labeled agents or cells, so that the negative contrast caused by these iron oxide-labeled agents can be better detected. Divalent manganese ion(Mn2+) is known as an excellent "positive", T1MRI contrast agent, which has recently been used for tracing of neuronal pathways, for enhancement of brain neuroarchitecture, and for functional MRI. Mn2+ can rapidly enter the parenchymal of most tissue including liver, kidney, muscle, and skin after systemic administration. Thus,it is expected that Mn2+ can shorten the T1 and yield better signal to noise per unit time for detecting negative contrast agents such as iron oxide particles. This information will be also useful for identifying and masking the signal voids due to local magnetic inhomogeneity or low signal areas such as air spaces and bone on T2 weighted MRI. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第１４回国際磁気共鳴医学会 | |||||
| 発表年月日 | ||||||
| 日付 | 2006-05-12 | |||||
| 日付タイプ | Issued | |||||
