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Dose-response Relationship of Thymic and Non-thymic Lymphomas Induction by Gamma Radiation in SCID Mice
https://repo.qst.go.jp/records/68614
https://repo.qst.go.jp/records/6861494caddab-f8dc-4c0a-814a-18e6bd702f52
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-08-03 | |||||
| タイトル | ||||||
| タイトル | Dose-response Relationship of Thymic and Non-thymic Lymphomas Induction by Gamma Radiation in SCID Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishii-Ohba, Hiroko
× Ishii-Ohba, Hiroko× Tsuji, Hideo× Nishimura, Mayumi× Kobayashi, Shigeru× Shimada, Yoshiya× Ogiu, Toshiaki× 石井 洋子× 辻 秀雄× 西村 まゆみ× 島田 義也× 荻生 俊昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | SCID mice which have the defect of DNA-dependent protein kinase catalytic subunit, exhibit the limited activities of repair from DNA double strand breaks and are sensitive to ionizing radiation. In order to study the relationship between repair capacity for DNA double strand breaks and carcinogenesis, and the responsibitily at the low dose of gamma rays, the effects of ionizing radiation on tumor induction were studied using scid homozygote (scid/scid), and C.B-17(+/+)mice. Carcinogenesis experiments showed the significant increase of the incidence of thymic lymphomas at 25cGy to sublethal dose. At very low dose(5 and 10cGy), non-thymic B or T cell lymphomas were incuced in scid mice, whereas there was no induction of these lymphomas in wild-type mice. No tumors other than lymphomas were observed, because of the life shortning effect by the induction of thymic lymphomas. Thus scid mice is highly sensitive to the induction of non-thymic lymphomas at very low doses. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 放射線影響学会第４６回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2003-10-08 | |||||
| 日付タイプ | Issued | |||||
