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Mammary gland serotonin is induced by prolactin and inhibits lactation in the mouse
https://repo.qst.go.jp/records/68537
https://repo.qst.go.jp/records/6853740983b9e-d5b4-47c2-9a50-6a97ca692505
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-26 | |||||
| タイトル | ||||||
| タイトル | Mammary gland serotonin is induced by prolactin and inhibits lactation in the mouse | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Matsuda, Manabu× J., Vomachka Archie× J., Mistry Meenakshi× A., Lockefeer Jason× D., Horseman Nelson× 今岡 達彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Many mammals have more than one mammary gland. Milk production is decreased in the gland with low milk consumption, while other glands continue milk synthesis. This study was undertaken to clarify the intragland feedback mechanism of milk production. First, tryptophan hydroxylase (TPH) and its downstream product serotonin (5-HT) were induced in the mammary epithelium of pituitary-grafted prolactin-deficient mice. Second, in the primary mammary epithelial cell culture, inhibitors of 5-HT signaling evoked morphological and molecular signs of activated lactation. Third, TPH mRNA was increased and milk protein mRNAs were decreased in unsuckled glands of lactating dams. Fourth, injection of a peripherally-acting inhibitor of 5-HT synthesis to the dam increased the milk intake of pups. These results support the idea that filling of the gland raised by lactogens increases the level of local TPH/5-HT, which in turn suppresses milk production. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Gordon Research Conferences Mammary Gland Biology | |||||
| 発表年月日 | ||||||
| 日付 | 2003-06-06 | |||||
| 日付タイプ | Issued | |||||
