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Carbon ion therapy in patients with pancreatic cancer
https://repo.qst.go.jp/records/68338
https://repo.qst.go.jp/records/683381dd6503f-b925-4ee6-b3cb-41af1ce6ba79
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-04-05 | |||||
| タイトル | ||||||
| タイトル | Carbon ion therapy in patients with pancreatic cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Katou, Hirotoshi× Yamaguchi, Kazuya× Kitabayashi, Hiroyuki× Yasuda, Shigeo× Miyamoto, Tadaaki× Tsujii, Hirohiko× 山田 滋× 加藤 博敏× 山口 和也× 北林 宏之× 安田 茂雄× 宮本 忠昭× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Adenocarcinoma of the pancreas continues to be a significant source of cancer mortality in Japan. Even after resection, the predicted 5-year survival rates are still less than 20%. Local recurrences in the pancreatic bed are seen in 50% of the patients undergoing presumed curative resection. We examined the effect of preoperative carbon ion therapy in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas. Between April 2000 and February 2003, 22 patients judged according to the staging criteria of the Japanese Committee on Cancer as being at clinical stages I,II,III or IVa were enrolled into this trial. Carbon ion therapy was given once daily, for a fixed 16 fractions in 4 weeks. The dose was set to 44.8GyE and escalated to 48.0GyE at 5% increments. All patients completed the scheduled treatment course. Of the 22 eligible patients, 14 were male and 8 female. Median age was 62 years. Three grade 3 acute reactions and two grade 3 late reactions occurred in 12 of the patients treated with a dose of 48.0GyE. Two of the grade 3 late reactions were attributed to by carbon ion therapy. Of the 22 patients, 15(63%) underwent resection. One of the 22 eligible patients did not undergo surgery because of liver metastasis. Of the 21 patients undergoing exploratory celiotomy, 6 did not undergo resection because three had metastases to the liver, and three to the peritoneum. All tumor specimens revealed evidence of pathological grade 2 treatment effects with significant fibrosis, hyalinization, and necrosis. The overall actuarial local control rates were 100% at 1 year and 100% at 2 years of follow-up, respectively. No local failure was observed in any of the 22 enrolled patients. The one year overall survival rates were 62%, 90 and 30%, respectively. The median overall survival times for the three groups were 15, 24 and 9 months, respectively. None of the patients who underwent resection had local and regional recurrences. The above results suggest the superior usefulness of heavy ion radiotherapy in the treatment of pancreatic carcinoma to conventional photon radiotherapy. A phase I/II Clinical trial of Carbon-ion therapy for patients with preoperative pancreas cancer(9906) was carried out on surgically resectable patients from June 2000 through February 2003. This was followed by a Phase I/II Clinical Trial of Short-course Carbon-ion therapy for patients with preoperative pancreas cancer (0203) commenced in April 2003 for similarly surgically resectable patients on a fractionation regimen from 16 (4 weeks) to 8 (2 weeks) fractions. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第106回 日本外科学会定期学術集会 国際シンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2006-03-31 | |||||
| 日付タイプ | Issued | |||||
