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Identification of signaling proteins involved in low-dose-specific cell survival induction in human breast cancer cells
https://repo.qst.go.jp/records/68312
https://repo.qst.go.jp/records/683128726108b-da68-49c5-b36f-21d2c82b5835
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-02-06 | |||||
| タイトル | ||||||
| タイトル | Identification of signaling proteins involved in low-dose-specific cell survival induction in human breast cancer cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakajima, Tetsuo
× Nakajima, Tetsuo× Nenoi, Mitsuru× 中島 徹夫× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation has been reported to induce low-dose-specific effects on cells. Adaptive response and low-dose hypersensitivity observed in some kinds of cell types suggest that low-dose irradiation induces cell survival relating repair processes. However the relationship between cellular effects and molecular processes remains unknown in low-dose-specific effects. Here we tried to investigate low-dose-specific cell survival induction using the human breast cancer cell line (MCF7). Five hours after the inoculation of MCF7 cells, the cells were irradiated at 0.1, 0.25 0.5 and 1Gy. The cell survival rates of the irradiated cells decreased dose-dependently at 0.1, 0.5 and 1Gy. However, at 0.25Gy the cell survival rate increased relatively in comparison with the other points. Using kinase-specific substrate antibodies, changes in signaling cascades were studied as a phosphoproteome analysis in cell survival induction. Signaling pathways in low-dose-specific cell survival induction will be discussed with the data showing culture condition dependency. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Keystone Symposia | |||||
| 発表年月日 | ||||||
| 日付 | 2006-02-04 | |||||
| 日付タイプ | Issued | |||||
