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Activation of IL-9 receptor and JAK-STAT cascade in Radiation-Induced Mice Thymic Lymphoma
https://repo.qst.go.jp/records/68244
https://repo.qst.go.jp/records/68244af7cd270-5e99-4d78-9e36-6115158d5228
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-11-19 | |||||
| タイトル | ||||||
| タイトル | Activation of IL-9 receptor and JAK-STAT cascade in Radiation-Induced Mice Thymic Lymphoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Amasaki, Yoshiko× Nishimura, Mayumi× Kobayashi, Yoshiro× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 甘崎 佳子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dysregulation of cytokine receptor expression and downstream signal transduction cascade play important roles in lymphomagenesis. In this study, we examined expression of cytokine receptors (IL-2R, 4R, 7R, 9R and 15R) and the activation status of downstream STAT pathways in mouse radiation-induced thymic lymphoma (TL) cells. TL was induced by exposure of TL-susceptible C57BL/6N(B6) mice and TL-resistant C3H/HeN(C3H) mice to split-dose X-irradiation (1.6Gy x 4 times). Expression of cytokine receptors was examined by semi-quantitative RT-PCR and western blotting. The results obtained here were as follows: (1) TL from B6 mice showed dramatically high expression of IL-9Ra compared to normal thymocytes by 60 folds, (2) IL-9Ra protein was also abundantly expressed and (3) high activation of STAT3 and STAT5, but not STAT1, were manifested in TL expressing high amount of IL9Ra. (4) In contrast to TL from B6, TL from C3H showed just 3-fold expression of IL9Ra compared to normal thymocytes. Activation of STATs was also much less compared to B6 TL. These findings suggested a correlation between the constitutive activation of STATs possibly resulting from IL-9Ra over-expression and the TL-susceptibility in mice. Investigations of phosphorylation of IL-9Ra, and activation of JAK1, which is associated with IL9Ra, are in progress. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第48回日本放射線影響学会／第1回アジア放射線研究会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2005-11-17 | |||||
| 日付タイプ | Issued | |||||
