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Prediction of radiation morbidity from polymorphisms in candidate genes among prostate cancer patients treated with carbon ion therapy.
https://repo.qst.go.jp/records/68218
https://repo.qst.go.jp/records/682187b16fcad-904f-46f0-8dcd-8702c4392758
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-11-02 | |||||
| タイトル | ||||||
| タイトル | Prediction of radiation morbidity from polymorphisms in candidate genes among prostate cancer patients treated with carbon ion therapy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference output | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iwakawa, Mayumi
× Iwakawa, Mayumi× Suga, Tomo× Noda, Shuhei× Tsuji, Hiroshi× Ootsuka, Yoshimi× Kouda, Masakazu× Sagara, Masashi× Ishikawa, Atsuko× Suzuki, Hideyuki× Mizoe, Junetsu× Tsujii, Hirohiko× Imai, Takashi× 岩川 眞由美× 菅 智× 野田 秀平× 辻 比呂志× 荘司 好美× 神田 将和× 相良 雅史× 石川 敦子× 鈴木 英幸× 溝江 純悦× 辻井 博彦× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heavy ion beams possess high linear energy transfer components and a prominent Bragg peak in the human body. These properties promote higher relative biological effectiveness and a favorable dose distribution. Some patients, however, develop adverse effects in the rectum and /or bladder/urethra. Using DNA samples collected from 95 Japanese prostate cancer patients who underwent radiotherapy with the Heavy Ion Medical Accelerator in Chiba, 905 SNPs were genotyped from 127 candidate genes for radiation susceptibility. These genes were selected from our previous gene expression analyses of cultured human cell lines and mouse strains that had exhibited variable radiosensitivities. The SNPs in the candidate genes were selected from jSNP and dbSNP databases and their allele frequencies were examined using 133 healthy controls. The acute and late radiation morbidities were scored using Late Effects of Normal Tissues-subjective, objective, management, and analytic criteria. Significant differences were observed of genotype frequencies for SNPs in candidate gene loci. Area under the curve of the Receiver Operating Characteristic Curve (ROC) was estimated for each SNP marker for radiation morbidity to construct a predictive score. The top 7 markers were used in constructing predictive scores for dysuria within 3 months, and the top 5 markers at 6 months after starting radiotherapy. The top 10 markers were used in constructing predictive scores for polyuria within 3 months, and the top 11 markers at 6 months after starting radiotherapy. The distribution of ten predictive scores according to response values showed the potential discriminating power of these analyses. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ASHG 55th Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2005-10-28 | |||||
| 日付タイプ | Issued | |||||
