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Expression of cell adhesion molecule L1 following exposure to irradiation during pregnancy in rats
https://repo.qst.go.jp/records/67973
https://repo.qst.go.jp/records/67973ef1a765a-5453-46a0-a703-3ff836ace512
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-12-14 | |||||
| タイトル | ||||||
| タイトル | Expression of cell adhesion molecule L1 following exposure to irradiation during pregnancy in rats | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
孫, 学智
× 孫, 学智× 高橋, 千太郎× 久保田, 善久× 佐藤, 宏× 張, 鋭× 崔, 春× 福井, 義浩× 孫 学智× 高橋 千太郎× 久保田 善久× 佐藤 宏 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To identify neuronal cell adhesion molecule L1 possibly involved abnormal neuronal migration induced by irradiation, expression of L1 in the brains were investigated through comparison between rats prenatally exposed to X-rays and controls. To observe the pattern of neuronal migration, bromodeoxyuridine was chosen as a marker to label migrating cells. The results showed some of the labeled cells remained in the lower of the cortical plate in the irradiated rats, suggesting that neuronal migration was disrupted by X-rays. To study changes in L1 expression, brain samples were analyzed by SDS-PAGE after isolation of L1 by immunoaffinity chromatography. In the all brain membrane fraction, immunoaffinity purified L1 had bands at 200, 180, 140 and 80 kDa. However, the bands in the irradiated group were very weak when compared with the control. Taking these results into account, abnormal neuronal migration and reduction in expression L1 found in the irradiated brain indicated that migration of neural cells may be dependent on neural cell molecule L1. A decrease in L1 expression may be one of reasons of abnormal neuronal migration. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第４7回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2004-11-27 | |||||
| 日付タイプ | Issued | |||||
