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HZE RADIATION EFFECT FOR HEREDITARY RETINAL CARCINOMAS
https://repo.qst.go.jp/records/67786
https://repo.qst.go.jp/records/67786fdc75b1f-79e6-46eb-aa35-23cddc7c02b9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-05-27 | |||||
| タイトル | ||||||
| タイトル | HZE RADIATION EFFECT FOR HEREDITARY RETINAL CARCINOMAS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nojima, Kumie
× Nojima, Kumie× Hino, Okio× et.al× 野島 久美恵× 樋野 興夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cancer is a heritable disorder of somatic cells. The Eker rat is well characterized as an animal model for dominantly inherited cancer. All of the Eker rats develop renal carcinomas (RC) approximately 1 year after birth. According to Mendelian laws of inheritance, this occurrence suggests the existence of a single responsible gene. Tuberous sclerosis complex (Tsc2) gene encoding a tumor suppressor protein, are the responsible factor for the RC. We have investigated the effects of space radiation on carcinogenesis and analyzed RBE ratio of tumor induction, in which we compared the effects of heavy-ion (C-290MeV/u,Fe-500MeV/u) exposure and X-ray exposure. Pregnant rats were irradiated by carbon-ions, iron-ions and X-rays by 0.5Gy, 1Gy, 2Gy and 3Gy individually on 19th day of gestation. These rats were sacrificed at age of 8 weeks, and organ weight and tumor genesis were measured. Thymus, Lung, Liver, Spleen weight were not different at 1Gy, but decreased by 50% at 3Gy irradiation. Kidney, Brain, Testis were radiation sensitive organs of which weight were decreased by 40% at 1Gy and by 80% at 3Gy. The number of hereditary renal carcinomas per one cross section of kidney were 3.7(1Gy), 42.0(3Gy) in the case of X-ray exposure, and 4. (1Gy) and 54.1(3Gy) by carbon ion exposure, and 14.5(1Gy) and 49.6(2Gy) by iron ion exposure. The Dose-response relationship on radiation-induced carcinoma was clearly fitted by LQ model. The RBE were observed as 1.1 for carbon-ions, and 1.6 for iron ions. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 3rd International Workshop on Space Radiation Resarch | |||||
| 発表年月日 | ||||||
| 日付 | 2004-05-20 | |||||
| 日付タイプ | Issued | |||||
