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Protective and Detrimental Bystander Effects Induced by X-Irradiation in the Limb Bud Cell Cultures of Fetal Mice
https://repo.qst.go.jp/records/67459
https://repo.qst.go.jp/records/67459fc87a1d9-cdb6-4b62-a98a-8462ca3004a2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-04 | |||||
| タイトル | ||||||
| タイトル | Protective and Detrimental Bystander Effects Induced by X-Irradiation in the Limb Bud Cell Cultures of Fetal Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Ohyama, Harumi× Shang, Yi× Yukawa, Osami× Aizawa, Shirou× Hayata, Isamu× 王 冰× 大山 ハルミ× 尚 奕× 湯川 修身× 相澤 志郎× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radioadaptive response and bystander effect represent important phenomena in radiobiology with an impact on the novel bioresponse mechanisms and risk estimates. The micromass cultures of limb bud cells (LBCs) provide an in vitro cellular maturation system, in which progress of cellular proliferation and differentiation is comparably paralleled to that of in vivo. This paper reports for the first time the evidential correlation and interaction, which simultaneously exist in the micromass culture system, between radioadaptive response and bystander effect. A radioadaptive response was induced in LBCs of embryonic day 11 (E11) ICR mice. Conditioning irradiation of the E11 cells with 30 cGy resulted in a significant protective effect against the occurrence of apoptosis, inhibition of cellular proliferation and differentiation induced by a challenging dose of 5 Gy given next day. Both protective and detrimental bystander effects were observed, namely, irradiating 50% of the E11 cells with 30 cGy led to a successful induction of radioadaptive response, and irradiating 70% of the E12 cells with 5 Gy produced comparably the detrimental effect to that of when all the cells were irradiated. Further, the bystander effects were markedly vanished by pretreatment of the cells with inhibitors to block the gap junction-mediated intracellular communication. These results indicated that the bystander effect played an important role in both the induction of a protective effect by the conditioning dose and the detrimental effect by the challenging irradiation. Concerning the underlying mechanism, the gap junction-mediated intracellular communication was suggested being involved in the induction of the bystander effects. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
