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Differentially expressed transcripts in Ikaros-defective lymphomas in irradiated B6C3F1 mice
https://repo.qst.go.jp/records/67451
https://repo.qst.go.jp/records/674519af6cb6a-ed5c-42a4-a598-c6c78683b7fb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-01 | |||||
| タイトル | ||||||
| タイトル | Differentially expressed transcripts in Ikaros-defective lymphomas in irradiated B6C3F1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yasumura, Kyoko
× Yasumura, Kyoko× Sugimura, Isamu× Kakinuma, Shizuko× Igarashi, Kazuei× Shimada, Yoshiya× 安村 今日子× 柿沼 志津子× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ikaros, a Kruppel type zinc finger protein, is essential for the normal lymphocyte development and differentiation. We have previously shown that Ikaros was frequently altered in radiation-induced T-cell lymphomas and assumed that Ikaros inactivation might have deep connection with developing leukemia. Although inactivation of Ikaros is inferred to be involved in leukemogenesis, little is known about the molecular mechanisms leading to neoplastic transformation. In order to identify the potential genes under the control of Ikaros, we performed differential display on RNAs from 3T3-L1 cells transfected with or without Ikaros. Finally, two cDNA, TRK-fused gene (Tfg) and death-associated protein 3 (Dap3), which were up-regulated by Ikaros, were identified. On the contrary, the expression status of Tfg and Dap3 in radiation-induced T-cell lymphomas, which had defect in Ikaros expression, was to be significantly decreased. Furthermore, we found that upstream the transcription start site of Tfg and Dap3 contain putative binding sites of Ikaros. These results suggest that Tfg and Dap3 are the candidates downstream of Ikaros, which are possibly involved in radiation-induced lymphomagenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
