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Role of Protein kinase C in radiation-induced apoptosis in mouse thymic lymphomas: Protein kinase C subtypes related to radiosensitivity and adaptive response
https://repo.qst.go.jp/records/67439
https://repo.qst.go.jp/records/67439892437e4-4bde-40c1-8ec5-e873da7caf1c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-27 | |||||
| タイトル | ||||||
| タイトル | Role of Protein kinase C in radiation-induced apoptosis in mouse thymic lymphomas: Protein kinase C subtypes related to radiosensitivity and adaptive response | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakajima, Tetsuo
× Nakajima, Tetsuo× Yukawa, Osami× Ohyama, Harumi× Bing, Wang× Hayata, Isamu× Inaba, Hiroko× 中島 徹夫× 湯川 修身× 大山 ハルミ× 王 冰× 早田 勇× 稲葉 浩子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Protein kinase C (PKC) is widely accepted to participate in the regulation of radiation-induced apoptosis.However, the function is not fully clarified. Here using 3SBH5 cells, one of the radiation sensitive thymic lymphoma cells, involvement of PKC was assessed in radiation-induced apoptosis related to radiosensitivity. It was demonstrated that Gö6976, a specific inhibitor of PKC (α or βI), promoted radiation-induced apoptosis in 3SBH5 cells and that the Ca2+-dependent PKC involving PKC (α or βI) was activated by irradiation with 50cGy. Therefore, the radiation-induced PKC (α or βI) activation was suggested to trigger PKC-mediated survival signal in 3SBH5 cells. During the apoptosis process, PKC (α or βI) distribution did not change in the cells. Moreover treatment with the PKC (α or βI) inhibitor 20min after irradiation had no effect on the radiation-induced apoptosis.Taken together, these results suggest that PKC (α or βI)-mediated survival signal is induced not through translocation of the PKC in the early period after irradiation. In order to analyze a mechanism of radiosensitivity, PKC signaling system in radioresistant cell line XR223 cells was compared with that in 3SBH5 cells. It was observed that the distribution of PKC δ was different between these cell lines. Mechanisms of PKC (α or βI) activation and PKC δ function are under investigation in these cell lines. It was suggested from the result of PKC activation by irradiation with 50cGy that the PKC-mediated survival signal participates in adaptive response to radiation. Role of PKC, highlighting the survival signal function, will be discussed from the viewpoint of radiosensitivity and adaptive response. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th Internatinal congress of radiation research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
