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Genomic Instability in Mutation Induction on Normal Human Fibroblasts Irradiated with Chronic Low-dose Radiations in Heavy-ion Radiation Field
https://repo.qst.go.jp/records/67432
https://repo.qst.go.jp/records/6743225111ba7-e4a1-4958-855f-359cb7ef71af
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-26 | |||||
| タイトル | ||||||
| タイトル | Genomic Instability in Mutation Induction on Normal Human Fibroblasts Irradiated with Chronic Low-dose Radiations in Heavy-ion Radiation Field | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Masao
× Suzuki, Masao× Tsuruoka, Chizuru× Uchihori, Yukio× Yasuda, Hiroshi× Fujitaka, Kazunobu× 鈴木 雅雄× 鶴岡 千鶴× 内堀 幸夫× 保田 浩志× 藤高 和信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Genomic Instability in Mutation Induction on Normal Human Fibroblasts Irradiated with Chronic Low-dose Radiations in Heavy-ion Radiation Field \nMasao Suzuki, Chizuru Tsuruoka, Yukio Uchihori, Hiroshi Yasuda and Kazunobu Fujitaka \nInternational Space Radiation Laboratory, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan. \nAt a time when manned space exploration is more a reality with the planned the International Space Station (ISS) underway, the potential exposure of crews in a spacecraft to chronic low-dose radiations in the field of low-flux galactic cosmic rays (GCR) and the subsequent biological effects have become one of the major concerns of space science. We have studied both in vitro life span and genomic instability in cellular effects in normal human skin fibroblasts irradiated with chronic low-dose radiations in heavy-ion radiation field. Cells were cultured in a CO2 incubator, which was set in the irradiation room for the biological study of heavy ions in the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS), and irradiated with scattered radiations produced from heavy ions. Absorbed dose measured using a thermoluminescence dosimeter (TLD) and a Si-semiconductor detector was to be around 1.4 mGy per day when operating the HIMAC machine for biological experiments. The total population doubling number (tPDN) of low-dose irradiated cells was significantly smaller (79-93%) than that of unirradiated cells. The results indicate that the life span of the cell population shortens by irradiating with low-dose scattered radiations in the heavy-ion irradiation field. Genomic instability in cellular responses was examined to measure either cell killing or mutation induction in low-dose accumulated cells after exposing to X-ray challenging doses. The results showed that there was no enhanced effect on cell killing between low-dose accumulated and unirradiated cells after exposing to defined challenging doses of 200kV X rays. On the contrary, the mutation frequency on hprt locus of low-dose accumulated cells was much higher than that of unirradiated cells. The results suggested that genomic instability was induced in mutagenesis by the chronic low-dose irradiations in heavy-ion radiation field. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-21 | |||||
| 日付タイプ | Issued | |||||
