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Responses of non-homologous end joining deficient human and rodent cells exposed to high LETparticles and X-rays
https://repo.qst.go.jp/records/67427
https://repo.qst.go.jp/records/674271075e2ab-a7c1-4582-a689-623f2bf0b764
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-25 | |||||
| タイトル | ||||||
| タイトル | Responses of non-homologous end joining deficient human and rodent cells exposed to high LETparticles and X-rays | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okayasu, Ryuichi
× Okayasu, Ryuichi× Takahashi, Sentaro× Kubota, Yoshihisa× Saitou, Shiori× Okada, Maki× 岡安 隆一× 高橋 千太郎× 久保田 善久× 斎藤 志織× 岡田 真希 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have measured cell survival levels in various human and rodent cell lines exposed to high LET (LET = 80 keV/um) carbon ion particles (290 MeV/u), and compared them with the survivals of the same cell lines exposed to X-rays. Non homologous end joining (NHEJ) deficient human fibroblasts (180 BR) irradiated with high LET carbon ions showed a survival level identical to that obtained with x-rays (RBE 1.0), while normal human fibroblasts showed a significantly higher cell survival obtained with x-rays than that with high LET carbon ions (RBE > 2.0 at 10% cell survival). NHEJ deficient hamster xrs6 cells (Ku 80 mutant) showed a 180BR-like survival response (RBE 1.5) and wild-type Chinese hamster ovary (CHO) cells showed a normal human cell-like response (RBE 2.2). When xrs6 cells corrected with the normal hamster Ku80 gene (Xrs6-haKu80) were used, the response was similar to that of wild-type CHO cells. These results suggest that the proteins associated with NHEJ may not play a major role in the recovery process of cells exposed to high LET radiation. We also studied interphase (G1) chromosome damage and repair in these cells with the premature chromosome condensation (PCC) technique. Those results are included as well. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
