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Atypical Behavioral and Neural Phenotypes in a Common Marmoset Model of Autism Spectrum Disorders
https://repo.qst.go.jp/records/66987
https://repo.qst.go.jp/records/66987207017cb-9a26-4729-9788-09daf0742f36
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-12-25 | |||||
| タイトル | ||||||
| タイトル | Atypical Behavioral and Neural Phenotypes in a Common Marmoset Model of Autism Spectrum Disorders | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mimura, Koki
× Mimura, Koki× Sato, Chika× Matsumoto, Jumpei× Aoki, Ichio× Ichinohe, Noritaka× Suhara, Tetsuya× Minamimoto, Takafumi× Mimura, Koki× Sato, Chika× Aoki, Ichio× Suhara, Tetsuya× Minamimoto, Takafumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Autism spectrum disorder (ASD) is a group of behaviorally defined neurodevelopmental disorders associated with social and cognitive disablities. In rodents, valproic acid (VPA) exposure in utero is widely used to an ASD model (Shin, 2015) because of its obvious surface fidelity. VPA has been reported as a risk factor of ASD in human clinical studies (Christensen, 2013). We have reported VPA exposed ASD model in non-human primate, common marmoset (Callithrix jacchus) (Yasue, 2015). Here we show brain structural and behavioral phenotypes in early developmental stage of this model. By using high-resolution diffusion tensor imaging (DTI) of neonatal marmosets brain, we found the size of the anterior commissure of ASD model marmosets (n=7) is significantly smaller than that of unexposed (UE) marmosets (n=9) (P2 day, p < 0.05). The kinship vocal communications in the family with ASD model child were longitudinally recorded. There were significant differences in call-use between VPA and UE families. In VPA families, frequency of social isolation call “phee” was increased, while “trill” call was decreased (P90 day, 9 VPA exposed, and 7 UE). These results suggested that VPA model marmosets have a risk of communication deficits at neonate, which is manifested by family social event, e.g. weaning. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International “Stress and Behavior” Society Regional Conference (Asia) | |||||
| 発表年月日 | ||||||
| 日付 | 2017-07-25 | |||||
| 日付タイプ | Issued | |||||
