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Development of a small prototype system toward real-time OpenPET image-guided surgery
https://repo.qst.go.jp/records/66291
https://repo.qst.go.jp/records/662913c0fd4b1-c37d-4e81-ae64-f34ca2465b62
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-10 | |||||
| タイトル | ||||||
| タイトル | Development of a small prototype system toward real-time OpenPET image-guided surgery | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
田島, 英朗
× 田島, 英朗× 吉井, 幸恵× 岩男, 悠真× 吉田, 英治× 脇坂, 秀克× 田桑, 弘之× 須尭, 綾× 張, 明栄× 山谷, 泰賀× Tashima, Hideaki× Yoshii, Yukie× Iwao, Yuma× Yoshida, Eiji× Wakizaka, Hidekatsu× Takuwa, Hiroyuki× Sugyo, Aya× Ming-Rong, Zhang× Yamaya, Taiga |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 1. Introduction Surgical operations are performed as the standard treatment for various types of cancers. However, it is challenging to remove all the tumors in one surgery if the tumors are widely and complexly distributed and they move with the organs or they are located on the backside of the organs. On the other hand, we are developing the OpenPET, which can provide accessible open space to the patient during PET scanning. In this study, we applied the open space for the image-guided surgery by the real-time OpenPET imaging. For a proof of concept, we developed a small prototype and conducted actual surgery to remove cancer tumors from a mouse. 2. Materials and Methods The proposed system was implemented on a small prototype of a single-ring OpenPET, which has the shape of a cylinder cut by two slanted parallel planes to form an open space. For real-time image reconstruction, we implemented the 3D DRAMA on the GPU. Human colon carcinoma HCT116-RFP cells had been intraperitoneally transplanted into a mouse. Twenty-four hours after intraperitoneal injection of anti-EGFR antibody cetuximab labeled with 64Cu, the mouse was set onto the operation table inside the FOV of the OpenPET for an abdominal operation. 3. Results and Discussion At first, we checked the tumor locations by the OpenPET imaging when the mouse was set on an operation stage. Measurement time required to acquire sufficient data to visually identify the tumors with clear contrast was about 10-30 s. Images were reconstructed with less than 1 s, and displayed images became gradually clearer every second. After removing the tumors and placing them outside the body, we could confirm by PET images that the tumors with radioactivity concentration had been appropriately resected. 4. Conclusion The surgery demonstrated that the system allowed us to confirm tumor positions anytime during the operation. The proposed system was effective in preventing any tumors, especially those located behind organs, from being left after the surgery. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 113th Scientific Meeting of the Japan Society of Medical Physics | |||||
| 発表年月日 | ||||||
| 日付 | 2017-04-13 | |||||
| 日付タイプ | Issued | |||||
