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α線放出核種211Atを用いた放射免疫療法
https://repo.qst.go.jp/records/65805
https://repo.qst.go.jp/records/6580528aa3425-268b-4a8e-b207-1c9891fbc127
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-11-11 | |||||
| タイトル | ||||||
| タイトル | α線放出核種211Atを用いた放射免疫療法 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
李, 惠子
× 李, 惠子× 長谷川, 純崇× 永津, 弘太郎× 佐賀, 恒夫× 李 惠子× 長谷川 純崇× 永津 弘太郎× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 【Objective】Astatine 211 (211At, T1/2=7.21h) is one of the attractive alpha emitter as it belongs to the same family as iodine, and the application into radioimmunotherapy (211At-RIT) is expected. We evaluated the biological effects of 211At-RIT both in vitro and in vivo.【Methods】211At was labeled with trastuzumab, anti-HER2 monoclonal antibody, using N-succinimidyl-3-(trimethylstannyl)benzoate. The in vitro cytotoxicity was evaluated by cell growth assay using a human metastatic gastric cancer cell line overexpressing HER2 protein. 211At-labeled trastuzumab, 0.5-2.5 MBq, was injected into mice bearing gastric cancer xenografts to determine the anti-tumor effect in vivo.【Results】211At-labeled trastuzumab showed significant cytotoxicity in vitro and suppressed tumor growth in vivo.【Conclusion】211At-RIT could be an effective treatment to HER2 overexpressing gastric cancer. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第55回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-11-06 | |||||
| 日付タイプ | Issued | |||||
