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Progesterone generates basal-like cancer stem cells via membrane progesterone receptor-triggered signaling
https://repo.qst.go.jp/records/65780
https://repo.qst.go.jp/records/65780022d19fe-420d-4128-b2ab-4cdcc7a5404d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-14 | |||||
| タイトル | ||||||
| タイトル | Progesterone generates basal-like cancer stem cells via membrane progesterone receptor-triggered signaling | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ
× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 崔, 星× 王, 冰× 藤森, 亮× 根井, 充× 中島, 徹夫× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 崔 星× 王 冰× 藤森 亮× 根井 充× 中島 徹夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Basal-like breast cancer is of particular concern, due to its high frequency, lack of effective therapies and poor prognosis. Ionizing radiation and cumulative exposure to steroid hormones are known risk factors for breast cancer. Because of their tumor-initiating properties, cancer stem cells (CSCs) were proposed to be responsible for relapse and metastasis. In MCF10A non-cancerous basal-like PR-negative cells, progesterone (P4) treatment and 1 Gy X-rays generated ALDH+ and CD44+/CD24- CSCs. Here, we report that P4 activated the Pi3k/Akt pathway via membrane progesterone receptor (mPR), resulting in the inactivation of FOXO transcriptional activity, the upregulation of snail and slug expression and a downregulation of miR-29 expression, which led to increased levels of KLF4, a transcription factor required for breast CSC maintenance. Stabilization of miR-29 expression impeded the generation of CSCs, while its inhibition alone was sufficient to generate CSCs. The elucidation of new pathways and miRNA regulations involved in basal-like CSC maintenance may open the door to new strategies for BBC primary or adjuvant therapy, which may be effective at preventing metastasis and relapse. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第７４回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-10-08 | |||||
| 日付タイプ | Issued | |||||
