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Novel Arterial Vascular Volume Elastic Modulus with Automated Oscillometric Approach Accurately Detected Endothelial and Endothelial Independent Vascular Function in CKD
https://repo.qst.go.jp/records/65725
https://repo.qst.go.jp/records/65725f7b162d2-85d8-4507-842a-e11f8274e8fd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-14 | |||||
| タイトル | ||||||
| タイトル | Novel Arterial Vascular Volume Elastic Modulus with Automated Oscillometric Approach Accurately Detected Endothelial and Endothelial Independent Vascular Function in CKD | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshinaga, Keiichiro
× Yoshinaga, Keiichiro× Tomiyama, Yuuki× Fujii, Satoshi× Nishio, Saori× Naoko, Matsuoka× Noriki, Ochi× Chietsugu, Katoh× Mamiko, Inoue× Nishida, Mutumi× M., Ito Yoichi× Tamaki, Nagara× 吉永 恵一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Simple and automated vascular function measurements are desirable for atherosclerosis risk assessments. Vascular elastic modulus (VE) is uninfluenced by blood pressure and is potentially linked to vascular function. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery´s VE and estimated arterial cross sectional area (eA). We aimed to investigate whether VE and eA response to nitroglycerin (NTG) reflected endothelial and endothelial independent dysfunction related to chronic kidney disease (CKD). Methods: 13 moderate-to-severe CKD (mean estimated glomerular filtration rate [eGFR]: 29.3±25.7 mL/min/1.73m2) and 15 controls were studied. Rest VE and eA response to NTG were measured by novel automated oscillometric detector. eA was estimated using pressure-volume curves and VE was defined as follows [VE=ΔPressure/ (100XΔarea/Area) mmHg/%]. Ultrasound measurements of flow mediated vasodilatation (FMD) and NTG were used as standard.Results: CKD had lower FMD than control (4.97±3.24 vs 9.03±2.98 %, P=0.002) and attenuated VE (1.09±0.25 vs 0.83±0.17 mmHg/%, P=0.003). Rest Ve was negatively correlated with %FMD(r=-0.43, P=0.02). Percent eA increase after NTG was correlated with %vascular diameter increase with ultrasound(r=0.51, P=0.005). However, there was no difference in %NTG(P=0.16) with ultrasound or %eA change (P=0.34) between the two groups.Conclusions: This new automated vascular function measurement using oscillometric measurement reliably detected endothelial dysfunction related to CKD and has potential to detect endothelial independent vasodilator response. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第79回日本循環器学会学術集会 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-04-26 | |||||
| 日付タイプ | Issued | |||||
