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Age-related white matter pathogenesis in a mouse model of tauopathy
https://repo.qst.go.jp/records/65696
https://repo.qst.go.jp/records/65696a6f2c117-e0b3-4e32-ac34-ec1233c105ff
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-28 | |||||
| タイトル | ||||||
| タイトル | Age-related white matter pathogenesis in a mouse model of tauopathy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sahara, Naruhiko
× Sahara, Naruhiko× Wen-Lang, Lin× Pablo, Perez× Higuchi, Makoto× Suhara, Tetsuya× Febo, Marcelo× Sahara, Naruhiko× Higuchi, Makoto× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Progressive tau pathology is associated with neuronal loss and white matter (WM) pathology in Alzheimer’s disease. WM degeneration in AD has been known from postmortem examinations. Diffusion tensor imaging (DTI) has provided significant insight into AD-associated reductions in WM integrity. Microstructural damage in WM may contribute the finding from DTI. However, a direct causal relation between DTI indices and specific AD-related pathologies is not established yet. Age-related alterations in WM diffusion anisotropy using in vivo DTI at 11.1 Tesla was measured in a mouse model of human tauopathy (rTg4510) and non-transgenic (non-tg) control mice at 2.5, 4.5, 8 months of age. Tau pathology in corpus callosum of transgenic mice was examined by immunohistochemistry and immunogold electron microscopy (IEM). The conformation specific tau antibody MC1-positive tau pathology in cortex and hippocampus was appeared as early as 1.5-2.5 months of age. However, there is no noticeable staining for MC1 antibody in corpus callosum of rTg4510 mice until 6 month-old. By IEM, aggregates of tau-positive filaments were detected in axons and swollen unmyelinated processed in 4 month-old and older rTg4510 mice. By DTI, 8 month-old rTg4510 mice showed lower fractional anisotropy (FA) values in WM structures than non-tg. The corpus callosum of 2.5 month-old rTg4510 mice showed a significantly reduced mode of anisotropy compared to non-tg controls. Our data support a role for the progression of tau pathology in reduced WM integrity measured by DTI. In vivo DTI studies in this mouse model provide better understanding for the mechanisms of WM pathogenesis and the specific role of tau during neurodegeneration. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Alzheimer’s Association International Conference 2014 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-07-13 | |||||
| 日付タイプ | Issued | |||||
