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Visualization of tau lesions in brains of tauopathy patients and model mice using tau ligand PBB3
https://repo.qst.go.jp/records/65695
https://repo.qst.go.jp/records/6569592e7e2f3-7d98-4b8c-a160-c932382d9e2e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-28 | |||||
| タイトル | ||||||
| タイトル | Visualization of tau lesions in brains of tauopathy patients and model mice using tau ligand PBB3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sahara, Naruhiko
× Sahara, Naruhiko× Ono, Maiko× Koga, Shunsuke× Maeda, Jun× Matsumoto, Izumi× W. Dickson, Dennis× K. Wszolek, Zbigniew× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto× Sahara, Naruhiko× Ono, Maiko× Maeda, Jun× Matsumoto, Izumi× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Association of tau deposition with neurodegeneration in Alzheimer’s disease (AD) and related tau-positive neurological disorders collectively referred to as tauopathies indicates contribution of tau aggregates to neurotoxicity. The discovery of tau gene mutations in FTDP-17-tau kindreds has provided unequivocal evidence that tau abnormalities alone can induce neurodegenerative disorders. Therefore, visualization of tau accumulation would offer a reliable, objective index to aid diagnosis of tauopathy and to assess the disease progression. Positron emission tomography (PET) imaging of tau lesions is currently available using several tau PET ligands including [11C]PBB3. PBB3 is a fluorescent compound, and is accordingly supposed to be useful for multimodal imaging studies, potentially allowing us to validate its binding to diverse tau inclusions by histological methods. In this study, we examined pathological characteristics of tau lesions in brains of human subjects with various tauopathies and tau transgenic mice. Double labeling of brain sections with tau oligomer specific antibody TOC1 and PBB3 demonstrated incorporation of tau oligomers in PBB3-positive tau lesions in old tau transgenic mice named rTg4510 mice, but the appearance of TOC1-positive tau inclusions preceded PBB3 signals. The numbers of TOC1- and PBB3-positive inclusions increased with aging in rTg4510 mice, while most PBB3-positive tau lesions in human AD brains, including ghost tangles, were not labeled with TOC1 antibody. These observations suggest that PBB3 reacts with mature tangles but not tau oligomers, and that tau oligomers in model mice and AD patients are distinctly involved in the formation of tau aggregates. Further in vitro histological/autoradiographic and in vivo PET studies are ongoing to validate the binding of PBB3 to tau lesions in AD and non-AD tauopathies. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2014北米神経科学学会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-11-17 | |||||
| 日付タイプ | Issued | |||||
