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アイテム
Research and development of the focused proton microbeam irradiation system, SPICE for radio-biological studies.
https://repo.qst.go.jp/records/65464
https://repo.qst.go.jp/records/65464ca35d244-2f45-40eb-a484-6f484c1b2e68
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-30 | |||||
| タイトル | ||||||
| タイトル | Research and development of the focused proton microbeam irradiation system, SPICE for radio-biological studies. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Konishi, Teruaki
× Konishi, Teruaki× Oikawa, Masakazu× Kobayashi, Alisa× Suya, Noriyoshi× Maeda, Takeshi× Uchihori, Yukio× Shirakawa, Yoshiyuki× 小西 輝昭× 及川 将一× 小林 亜利紗× 酢屋 徳啓× 前田 武× 内堀 幸夫× 白川 芳幸 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There is continuing interest for the use of microbeam irradiation systems designed to deliver a defined number of charged particles on a single cell with a resolution of a few micrometers. Moreover, microbeams are articularly useful for the field of radiation-induced non-targeted effects, so-called bystander effects that are considered to be one of the major effects in the low-dose region. Thus, microbeam technique is one of the powerful tools for investigating studies related to radiation effect and risk of low dose in space radiation for astronauts and cosmonauts. Our microbeam irradiation system, the Single-Particle Irradiation system to CEll (SPICE) provides a 3.4 MeV proton microbeam focused with a quadrupole magnetic lens on an upward vertical beam line.[1] SPICE was severely damaged by the Tohoku Earthquake on 11 March 2011, and was out of operation for about a year and a half. We have successfully reconstructed the facility, and it is now operational with system refinements. At present, SPICE is the only proton microbeam facility in Japan at which a single-ion single-cell irradiation can be performed on mammalian cells with stability and high throughput using an upward vertical beam of below 2 μm diameter, focused with a magnetic quadrupole triplet lens. A variety of irradiation modes have been established for radiation-induced bystander effects, cytoplasm irradiation, and multi-position targeting mode. [2] Most of all, SPICE has been administrated as a ‘Joint-use facility for Collaborative Research’, and thus researchers outside NIRS can apply for beam time of SPICE after their research proposals are approved. In the past two years, other than 4 internal applications (2 from Charged Particle Therapy Center, 1 from Radiation Emergency Center, 1 from Research and Development Support center), total of 8 external applications from 3 domestic and 5 foreign Universities and Institutions were performed. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
