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Controlled administration of penicillamine reduces radiation exposure to normal organs in 64Cu-ATSM internal radiotherapy
https://repo.qst.go.jp/records/65050
https://repo.qst.go.jp/records/65050f8e817d0-88f1-4fca-8422-847ca2f2d651
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-20 | |||||
| タイトル | ||||||
| タイトル | Controlled administration of penicillamine reduces radiation exposure to normal organs in 64Cu-ATSM internal radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshii, Yukie
× Yoshii, Yukie× Matsumoto, Hiroki× Yoshimoto, Mitsuyoshi× Furukawa, Takako× Morokoshi, Yukie× Sogawa, Chizuru× Zhang, Ming-Rong× Wakizaka, Hidekatsu× Fujibayashi, Yasuhisa× Saga, Tsuneo× 吉井 幸恵× 松本 博樹× 吉本 光喜× 古川 高子× 諸越 幸恵× 曽川 千鶴× 張 明栄× 脇坂 秀克× 藤林 康久× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) is a promising internal radiotherapy (IRT) agent targeting tumor hypoxia. However, for clinical application of 64Cu-ATSM IRT, reduction of radiation to dose-limiting organs such as liver and intestines is critical. Here we developed a method to reduce radiation doses to normal organs while preserving tumor radiation dose by controlled administration of penicillamine, a copper chelator, in 64Cu-ATSM IRT. Methods: To examine effects of penicillamine, in vivo biodistribution studies were performed with HT-29 tumor-bearing mice with/without penicillamine administration. First, optimal injection interval of 64Cu-ATSM and penicillamine was tested. Optimal injection doses of penicillamine were then determined among single-dose administration of 100, 300 and 500 mg/kg at 1 h after 64Cu-ATSM injection or fractionated administration (100 mg/kg x 3) started at 1 h after 64Cu-ATSM injection with 1- or 2-h intervals. PET study and dosimetry analysis were also performed. Results: Penicillamine administration decreased 64Cu retention in liver and small intestine. Tumor uptake was not affected by penicillamine administration at 1 h after 64Cu-ATSM injection, but administration at 10 min before and after 64Cu-ATSM injection reduced tumor uptake. For single-dose injection, 300 mg/kg was optimal. Fractionated administration showed almost similar effect to single-dose injection, while inducing further prolonged decrease of liver retention. PET study showed same results as biodistribution study. Dosimetry analysis demonstrated controlled penicillamine administration enables to suppress radiation doses to critical organs below the tolerance levels in 64Cu-ATSM IRT. Conclusion: Controlled administration of penicillamine can reduce radiation exposure to normal organs in 64Cu-ATSM IRT, suggesting this method could be useful in clinical settings. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNMMI 2013 Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2013-06-12 | |||||
| 日付タイプ | Issued | |||||
