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Using animal models, we studied the age-at-exposure effect of radiation on cancer induction and lifespan shortening, in order to propose age-weighting factors and relative biological effectiveness (RBE) of heavy ions for radiation protection of fetuses and children. \nFifty female and male B6C3F1 mice per group were exposed to gamma rays (137Cs) or carbon ions (13 keV/\u0026micro;m) at various ages from fetal to mature adult periods.  Mouse ages at the time of irradiation included 3 days post-conception (dpc), 13 dpc, 17 dpc, and 1 week, 3 weeks, 7 weeks and 15 weeks after birth. The doses ranged between 0.2 and 4 Gy for gamma rays and 0.2 and 2 Gy for carbon ions. The mice were observed until moribund and their lifespan and tumor burden were analyzed.\nFemale mice appeared to be more susceptible to radiation-induced lifespan shortening than male mice. The effect of gamma-rays on lifespan shortening was more pronounced when irradiated at 1 week rather than 7 weeks of age. 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  1. 学会発表・講演等
  2. 口頭発表

Lifespan shortening after exposure of mice to gamma-rays or carbon ions during fetal, childhood and adult periods

https://repo.qst.go.jp/records/65043
https://repo.qst.go.jp/records/65043
ed81d947-9405-4ca4-8d5b-a3f323524c2b
Item type 会議発表用資料 / Presentation(1)
公開日 2013-06-11
タイトル
タイトル Lifespan shortening after exposure of mice to gamma-rays or carbon ions during fetal, childhood and adult periods
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 640921

Kakinuma, Shizuko

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Shang, Yi

× Shang, Yi

WEKO 640922

Shang, Yi

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Amasaki, Yoshiko

× Amasaki, Yoshiko

WEKO 640923

Amasaki, Yoshiko

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Hirano, Shinobu

× Hirano, Shinobu

WEKO 640924

Hirano, Shinobu

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Sawai, Tomoko

× Sawai, Tomoko

WEKO 640925

Sawai, Tomoko

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Takabatake, Takashi

× Takabatake, Takashi

WEKO 640926

Takabatake, Takashi

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Sawa, Yurika

× Sawa, Yurika

WEKO 640927

Sawa, Yurika

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Shirakami, Ayana

× Shirakami, Ayana

WEKO 640928

Shirakami, Ayana

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Sunaoshi, Masaaki

× Sunaoshi, Masaaki

WEKO 640929

Sunaoshi, Masaaki

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Morioka, Takamitsu

× Morioka, Takamitsu

WEKO 640930

Morioka, Takamitsu

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Tsuruoka, Chizuru

× Tsuruoka, Chizuru

WEKO 640931

Tsuruoka, Chizuru

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Tani, Shusuke

× Tani, Shusuke

WEKO 640932

Tani, Shusuke

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Blyth, Benjamin

× Blyth, Benjamin

WEKO 640933

Blyth, Benjamin

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 640934

Nishimura, Mayumi

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Imaoka, Tatsuhiko

× Imaoka, Tatsuhiko

WEKO 640935

Imaoka, Tatsuhiko

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Daino, Kazuhiro

× Daino, Kazuhiro

WEKO 640936

Daino, Kazuhiro

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Takeda, Shino

× Takeda, Shino

WEKO 640937

Takeda, Shino

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Iwata, Ken-ichi

× Iwata, Ken-ichi

WEKO 640938

Iwata, Ken-ichi

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Yamada, Yutaka

× Yamada, Yutaka

WEKO 640939

Yamada, Yutaka

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 640940

Shimada, Yoshiya

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柿沼 志津子

× 柿沼 志津子

WEKO 640941

en 柿沼 志津子

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尚 奕

× 尚 奕

WEKO 640942

en 尚 奕

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甘崎 佳子

× 甘崎 佳子

WEKO 640943

en 甘崎 佳子

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坂入 しのぶ

× 坂入 しのぶ

WEKO 640944

en 坂入 しのぶ

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澤井 知子

× 澤井 知子

WEKO 640945

en 澤井 知子

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高畠 貴志

× 高畠 貴志

WEKO 640946

en 高畠 貴志

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澤 百合香

× 澤 百合香

WEKO 640947

en 澤 百合香

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白神 綾奈

× 白神 綾奈

WEKO 640948

en 白神 綾奈

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砂押 正章

× 砂押 正章

WEKO 640949

en 砂押 正章

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森岡 孝満

× 森岡 孝満

WEKO 640950

en 森岡 孝満

Search repository
鶴岡 千鶴

× 鶴岡 千鶴

WEKO 640951

en 鶴岡 千鶴

Search repository
谷 修祐

× 谷 修祐

WEKO 640952

en 谷 修祐

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Blyth Benjamin

× Blyth Benjamin

WEKO 640953

en Blyth Benjamin

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西村 まゆみ

× 西村 まゆみ

WEKO 640954

en 西村 まゆみ

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今岡 達彦

× 今岡 達彦

WEKO 640955

en 今岡 達彦

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臺野 和広

× 臺野 和広

WEKO 640956

en 臺野 和広

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武田 志乃

× 武田 志乃

WEKO 640957

en 武田 志乃

Search repository
岩田 健一

× 岩田 健一

WEKO 640958

en 岩田 健一

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山田 裕

× 山田 裕

WEKO 640959

en 山田 裕

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島田 義也

× 島田 義也

WEKO 640960

en 島田 義也

Search repository
抄録
内容記述タイプ Abstract
内容記述 There are insufficient data at present to inform cancer risk after radiation exposure, during fetal and childhood periods, especially for heavy ions. Using animal models, we studied the age-at-exposure effect of radiation on cancer induction and lifespan shortening, in order to propose age-weighting factors and relative biological effectiveness (RBE) of heavy ions for radiation protection of fetuses and children.
Fifty female and male B6C3F1 mice per group were exposed to gamma rays (137Cs) or carbon ions (13 keV/µm) at various ages from fetal to mature adult periods. Mouse ages at the time of irradiation included 3 days post-conception (dpc), 13 dpc, 17 dpc, and 1 week, 3 weeks, 7 weeks and 15 weeks after birth. The doses ranged between 0.2 and 4 Gy for gamma rays and 0.2 and 2 Gy for carbon ions. The mice were observed until moribund and their lifespan and tumor burden were analyzed.
Female mice appeared to be more susceptible to radiation-induced lifespan shortening than male mice. The effect of gamma-rays on lifespan shortening was more pronounced when irradiated at 1 week rather than 7 weeks of age. Surprisingly, irradiation with gamma rays at the late fetal stage had little influence on lifespan shortening compared to infant and adult exposures. Carbon ions were more potent in reducing lifespan than gamma rays when 1 week-old mice were exposed. In the case of carbon ions, however, fetuses were still susceptible as infants. The results on lifespan shortening suggest a larger RBE of carbon ions for fetuses compared to later stages. But, if acute non-cancer effects were excluded, the survival curve for fetuses was similar to that for later ages.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 Heavy Ion in Therapy and Space Radiation Symposium 2013
発表年月日
日付 2013-05-18
日付タイプ Issued
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