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Significant tumor radio-sensitization by the combined treatment of hsp90 inhibitor and heavy ion irradiation in vivo
https://repo.qst.go.jp/records/64751
https://repo.qst.go.jp/records/64751282ad2d3-d8e7-42be-8da1-f8ec4d786a21
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-24 | |||||
| タイトル | ||||||
| タイトル | Significant tumor radio-sensitization by the combined treatment of hsp90 inhibitor and heavy ion irradiation in vivo | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okayasu, Ryuichi
× Okayasu, Ryuichi× Hirakawa, Hirokazu× Noguchi, Miho× Hirayama, Ryoichi× Fujimori, Akira× 岡安 隆一× 平川 博一× 野口 実穂× 平山 亮一× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have shown the radio-sensitizing effect by an hsp90 inhibitor 17AAG in human tumor cells exposed to X-rays, and suggested that this effect was due to inhibition of the homologous recombination (HR) pathway of DNA DSB repair. Surprisingly, tumor radiosensitization with 17 AAG pre-treatment was also observed in cells exposed to high LET carbon ions (70 keV/micro-m). Independently we found that knockdown of BRCA2, a key HRR protein significantly radiosensitized human tumor cells exposed to heavy ions. Using mouse xenograft model, we further examined the combined effect of 17AAG and high LET radiation. SQ5 human lung tumor cells were implanted on the leg of nude mice and the tumor growth was observed under various conditions. Our results indicate that tumor growth was more controlled in the 17AAG treatment combined with carbon irradiation than carbon or 17AAG treatment alone. The growth inhibition by 17AAG in high LET heavy ion treated tumors was more pronounced than the combined treatment with 17AAG and X-rays. These data suggest that the most effective tumor control might be obtained by combining an HRR inhibitor with high LET carbon ion irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第7１回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-09-21 | |||||
| 日付タイプ | Issued | |||||
