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Direct action is the key to understand the high biological effects caused by particle beams
https://repo.qst.go.jp/records/64625
https://repo.qst.go.jp/records/64625bcb01c79-05dc-44f5-b3ab-8b8acf8d426b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-06-15 | |||||
| タイトル | ||||||
| タイトル | Direct action is the key to understand the high biological effects caused by particle beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Matsumoto, Yoshitaka× Uzawa, Akiko× Takase, Nobuhiro× Tsuruoka, Chizuru× Wada, Mami× Noguchi, Miho× Kase, Yuki× Matsufuji, Naruhiro× Ito, Atsushi× Okayasu, Ryuichi× Furusawa, Yoshiya× 平山 亮一× 松本 孔貴× 鵜澤 玲子× 鶴岡 千鶴× 和田 麻美× 松藤 成弘× 伊藤 敦× 岡安 隆一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The contribution of indirect action mediated by OH radicals in cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide (DMSO), which suppresses indirect action of radiation without affecting direct action. Exponentially growing Chinese hamster ovary cells under oxic and hypoxic conditions were exposed to X-rays and iron ions having a dose-averaged LET at 200 keV/micrometer in the presence or absence of DMSO, and the cell survival was determined using the colony formation assay. The contributions of indirect action of 76% and 50% were found for X-rays under oxic and hypoxic conditions, respectively. In contrast, the contributions of indirect action for iron ions were estimated to be 42% and 32%. The RBE values were 2.8 for oxic and 5.3 for hypoxic, and the OER values were 2.8 for X-rays and 1.5 for iron ions. When the RBE and OER were estimated separately for direct action (RBED and OERD) and indirect action (RBEI and OERI); the RBED was larger than RBEI under both normal and low oxygen concentrations. The OERD values for both X-rays and iron ions were lower than that for OERI. Thus, direct action of radiation gives a remarkably higher RBE and lower OER for cell killing than indirect action. It is possible that particle beams may be highly effective in treating cancer if the particle therapy can only use the portion of direct action out of total radiation actions; this would be exemplified by the usage of radioactive 9C-ion beams and boron neutron capture. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International Workshop on Radiation Damage to DNA | |||||
| 発表年月日 | ||||||
| 日付 | 2012-06-07 | |||||
| 日付タイプ | Issued | |||||
