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In-vivo detection of cell cycle arrest using manganese-enhanced MRI (MEMRI)
https://repo.qst.go.jp/records/64245
https://repo.qst.go.jp/records/64245866e4fef-b467-4447-aceb-4e65706d9a39
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-16 | |||||
| タイトル | ||||||
| タイトル | In-vivo detection of cell cycle arrest using manganese-enhanced MRI (MEMRI) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saito, Shigeyoshi
× Saito, Shigeyoshi× Hasegawa, Sumitaka× Furukawa, Takako× Saga, Tsuneo× Aoki, Ichio× 齋藤 茂芳× 長谷川 純崇× 古川 高子× 佐賀 恒夫× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | INTRODUCTION Recent studies on the utility of manganese have shown that manganese-enhanced MRI (MEMRI) can detect cellular alterations in tumor models [1][2]. In addition, the intercellular contrast agent MnCl2 has been successfully used to assess cell viability in heart ischemia [3], and cells can be easily labeled using Mn2+ in vitro [4]. Hasegawa et al. reported that MEMRI can reflect MnSOD over-expression in a tumor model [2]. Radiotherapy using high-energy x-rays treats malignancies with the intention of destroying or inactivating cells while preserving normal tissue integrity. We investigated the relationship between x-ray irradiation and Mn uptake in tumor cells and tested whether MEMRI can detect radiation-induced cell disturbances at an early stage both in vitro and in vivo. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ＩＳＭＲＭ 19ｔｈ Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ | |||||
| 発表年月日 | ||||||
| 日付 | 2011-05-13 | |||||
| 日付タイプ | Issued | |||||
