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Estimation of in-vivo and clinical response for therapeutic carbon ions by LQ and RCR models
https://repo.qst.go.jp/records/63890
https://repo.qst.go.jp/records/63890e5637d0f-02df-406a-b7c2-e9d05f95ea13
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-24 | |||||
| タイトル | ||||||
| タイトル | Estimation of in-vivo and clinical response for therapeutic carbon ions by LQ and RCR models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference output | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsufuji, Naruhiro
× Matsufuji, Naruhiro× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Estimation of in-vivo and clinical response for therapeutic carbon ions by LQ and RCR models \nNaruhiro Matsufuji, Mami Wada, Yuki Kase, Yoshitaka Matsumoto, Yoshiya Furusawa, Akiko Uzawa and Koichi Ando \nResearch Center for Charged Particle Therapy, National Institute of Radiological Sciences1), Graduate School of Science, Chiba University2) and Heavy Ion Medical Center, Gunma University3) \nPurpose Hypofractionated irradiation is one of the attractive advantages of carbon ions for cancer therapy due to its superior dose localization realized by elevating energy loss toward range end and associated increasing biological effectiveness. At HIMAC (Heavy Ion Medical Accelerator in Chiba), the efficacy of hypofractionation has been investigated in most tumor sites, and ultimately one-day irradiation has been tried against NSCLC (non-small cell lung cancer). Due to its simplicity and sufficient precision in conventional radiotherapy modality, LQ (linear-quadratic) model has been preferred for the estimation of biological or clinical response for radiation. In hypofractionated radiotherapy, however, the absorbed dose given to tumor is far beyond the range where the LQ model has been experimentally verified. Here, recently-proposed RCR (Repairable-Conditionally Repairable) model is expected to be applicable in wider dose range. In this study, these models are applied for the estimation of in-vivo as well as clinical response for carbon ions. \nMethod From single up to 6 fractionated irradiation experiments have been conducted at HIMAC BIO cave with carbon ions of various LETs and X-rays to mice. Endpoint of the experiment is the incidence of grade 2 on skin, i.e., a complete epilation with or without slight edema. The derived isoeffective dose is plotted on the Fe-plot together with the estimation by LQ and RCR model. LQ or RCR model is in its basic form used for the estimation of cell survival probability. By taking the number of clonogens in a tumor into this estimation of cell survival, TCP (tumor control probability) can be estimated. With the models, isoeffective clinical dose was estimated and compared with the local control rate of NSCLC with carbon ions derived at HIMAC. \nResult and conclusion The experimental result of mice shows a drop in response on single irradiation. This drop is unique to carbon ion irradiation, i.e., not observed in X-ray irradiation. The conventional LQ model shows dissociation in response between single and multiple irradiations of carbon ions. RCR model is found useful in reproducing data up to single irradiation. LET dependency of parameters used in the RCR model suggests that cluster-like, less repairable lesions are produced significantly in high LET irradiation. The result of TCP estimation and the comparison with clinical data will be reported in the presentation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PTCOG49 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-05-22 | |||||
| 日付タイプ | Issued | |||||
