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Meta-Analysis of Secondary Cancer in Childhood Cancer Survivors
https://repo.qst.go.jp/records/63874
https://repo.qst.go.jp/records/638745960bf00-b4e1-41b9-b349-e794d6935985
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-04-21 | |||||
| タイトル | ||||||
| タイトル | Meta-Analysis of Secondary Cancer in Childhood Cancer Survivors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Doi, Kazutaka
× Doi, Kazutaka× Mieno, Makiko× Shimada, Yoshiya× Yonehara, Hidenori× Yoshinaga, Shinji× 土居 主尚× 三重野 牧子× 島田 義也× 米原 英典× 吉永 信治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Cancer risks following radiotherapy have not been well characterized in terms of radiation dose. Before we have conducted a meta-analysis of studies on the excess relative risk per Gy (ERR) of second malignant neoplasm (SMN) among childhood cancer survivors, but the small number of eligible studies restricted quantitative evaluations. To solve this problem, we developed a statistical method to calculate an ERR estimate from other estimates, and conducted a meta-analysis again. Materials and Methods: We searched the PubMed database, and 21 studies were identified. ERR estimates were available in 10 studies, and for the rest 11 studies, we used the regression-based model to calculate a ERR estimate from other estimates. The overall ERR estimates of radiotherapy were calculated using a random effects model. Results and Discussion: The ERR estimates from 21 studies ranged from 0.004 to 11.7. The overall ERR was 0.45 (95%CI: 0.21, 0.97), which was far smaller than the corresponding estimate of 1.7 from the study on atomic bomb survivors exposed as young children. Heterogeneity was suggested by Cochran's Q statistics (Q=188, DF=20, p<0.001). The reason for heterogeneity will be explored. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | WHO satellite meeting "Radiation risk assessment in pediatric healthcare" in KIDS Workshop 2009 in NIRS | |||||
| 発表年月日 | ||||||
| 日付 | 2009-12-17 | |||||
| 日付タイプ | Issued | |||||
