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重粒子線照射によるゲノム構造と遺伝子発現量の変化
https://repo.qst.go.jp/records/63855
https://repo.qst.go.jp/records/6385553ca4797-715b-4cd9-a191-c9e85e535b5a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-26 | |||||
| タイトル | ||||||
| タイトル | 重粒子線照射によるゲノム構造と遺伝子発現量の変化 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
道川, 祐市
× 道川, 祐市× 石川, 顕一× 藤田, 真由美× 盛武, 敬× 岩川, 眞由美× 道川 祐市× 石川 顕一× 藤田 真由美× 盛武 敬× 岩川 眞由美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim of this study is to understand cellular and molecular nature of cancer cells survived for long term after charged particle exposure. During the period of 1st year, clonogenic sensitivity of various cancer cell lines against charged particles was investigated by two experimental strategies. Firstly, mouse cancer cell line analysis in the presence of 5-azacytidine, a DNA methylation inhibitor, revealed epigenetic heterogeneity of charged particle sensitivity within the cell population. In the second approach, human glioblastoma cell line, Becker, was investigated for the phenotypic changes after long term survival period (3 weeks). Especially, the cells were revealed to be sensitized toward secondary exposure of charged particles in a way of primary dose-dependence. However, this tendency was clearly eliminated when cells were treated by 5-azacytidine before the primary exposure. Thus, epigenetic regulations of cellular genomic DNA were also supposed to play important roles in the radiation sensitivity changes of the long-term survived cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H20年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-04-14 | |||||
| 日付タイプ | Issued | |||||
