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アイテム
PETによるタウオパチーモデルマウス神経変性病理の検出
https://repo.qst.go.jp/records/63839
https://repo.qst.go.jp/records/638399c3e1501-5815-488b-9813-3e405dfd91b2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-15 | |||||
| タイトル | ||||||
| タイトル | PETによるタウオパチーモデルマウス神経変性病理の検出 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
服部, 聡子
× 服部, 聡子× 丸山, 将浩× 関, 千江× 季, 斌× 前田, 純× 岡内, 隆× 樋口, 真人× 須原, 哲也× その他× 服部 聡子× 丸山 将浩× 関 千江× 季 斌× 前田 純× 岡内 隆× 樋口 真人× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positron emission tomography (PET) has been conducted in patients with neurodegenerative diseases, but the neuropathological basis of the PET findings remains elusive, due to the lack of animals modeling the chronic, progressive neurodegeneration. Here, we performed combined microPET and histological examinations of tau transgenic mice showing age-dependent deteriorations leading to massive neuronal loss. The cerebral glucose utilization measured by [18F]fluorodeoxyglucose and neuroinflammation quantified by a radioligand for translocator proteins (TSPOs) were positively correlated with the number of neurons and magnitude of gliosis, respectively. The TSPO upregulation was noticeable in brains with minimal atrophies, supporting its significance as an early pathological marker. Meanwhile, the glucose hypometabolism was linearly proportional to the loss of neurons, and thus can be an index reflecting the severity of the neurodegeneration. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第32回日本神経科学大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-09-18 | |||||
| 日付タイプ | Issued | |||||
