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子宮頸癌生検試料における放射線治療応答マーカーFGF２の発現
https://repo.qst.go.jp/records/63598
https://repo.qst.go.jp/records/63598183263ff-bdc4-4ed3-9a96-c56566dc2afd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-05 | |||||
| タイトル | ||||||
| タイトル | 子宮頸癌生検試料における放射線治療応答マーカーFGF２の発現 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
岩川, 眞由美
× 岩川, 眞由美× 中渡, 美也子× 今留, 香織× 中村, 悦子× 酒井, 美奈子× 大野, 達也× 加藤, 真吾× 大久保, 悠× 今井, 高志× 岩川 眞由美× 中渡 美也子× 今留 香織× 中村 悦子× 酒井 美奈子× 大野 達也× 加藤 眞吾× 大久保 悠× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Our previous research suggested FGF2 expression change would be an indicator for the efficacy of radiotherapy. Here, we validated this finding using newly enrolled patients and further investigated the mechanism of individual tumor radiosensitivity related with the FGF2 expression. Experimental design: Sixty-nine patients were recruited as a validation set for immunohistichemical FGF2 expression in tumor cells (FGF2-T), using biopsy samples taken before or one week after initiation of radiotherapy. We also investigated the expression of FGF2 in tumor stroma (FGF2-S), VEGF and CD31 in 98 patients. Results: FGF2-T significantly increased (P = 0.0037), and the ratio change of FGF2-T was significantly related with better prognosis (P = 0.028). Only tumors with positive FGF2-S in pretreatment samples increased VEGF expression (P = 0.035). Conclusions: We confirmed our previous report for FGF2-T expression change. We also found the relationship between FGF2-S and VEGF during radiotherapy. These findings are indicative of the importance of combination timing and strict selection of patients in molecular target therapy after standard-of-care treatment. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第68回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-03 | |||||
| 日付タイプ | Issued | |||||
