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Effects of antipsychotic drug on dopamine synthesis in humans measured by PET with [C-11]DOPA
https://repo.qst.go.jp/records/63122
https://repo.qst.go.jp/records/63122e77db126-0366-4376-9c85-b21992e7cc44
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-06-23 | |||||
| タイトル | ||||||
| タイトル | Effects of antipsychotic drug on dopamine synthesis in humans measured by PET with [C-11]DOPA | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Takano, Harumasa× Takahashi, Hidehiko× Arakawa, Ryosuke× Suhara, Tetsuya× 伊藤 浩× 高野 晴成× 高橋 英彦× 荒川 亮介× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Effects of antipsychotic drugs have been considered to be mediated by blockade of dopamine D2 receptors. In this study, changes in dopamine synthesis rate by administration of second-generation antipsychotics were measured by PET. Methods: PET studies were performed on 12 healthy men under resting condition (baseline study) and oral administration of single dose of antipsychotic drug, risperidone of 0.5-2.0 mg, (drug challenge study) on separate days. In each study, both PET scans with [C-11]raclopride and [C-11]DOPA were performed sequentially. The occupancy of dopamine D2 receptors by risperidone was calculated from binding potential values in the striatum for baseline and drug challenge studies with [C-11]raclopride determined by the SRTM method. The uptake rate constant, Ki, for [C-11]DOPA in the striatum indicating the dopamine synthesis rate was estimated by the graphical analysis. Results: The occupancies of dopamine D2 receptors were 39%-75%. The dopamine synthesis rate Ki were 0.0136+-0.0017 and 0.0142+-0.0010 (1/min) for the baseline and drug challenge studies, respectively, and no significant change in Ki by risperidone was observed. A significant negative correlation was observed between the baseline Ki and the change in Ki by risperidone (r=-0.87). Conclusions: The negative correlation between the baseline Ki and the change in Ki by risperidone, and smaller coefficient of variation of Ki in drug challenge studies than in baseline studies indicate that risperidone can be considered to stabilize the level of dopamine synthesis rate. Therapeutic effects of risperidone on schizophrenia might be related to stabilizing effects on dopaminergic neurotransmission responsivity in dopamine release. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNM 2009 Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2009-06-17 | |||||
| 日付タイプ | Issued | |||||
