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重粒子線の生物効果の細胞周期の影響
https://repo.qst.go.jp/records/62886
https://repo.qst.go.jp/records/62886b7a4941d-f535-4399-a9fe-d0520baaa633
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-11-26 | |||||
| タイトル | ||||||
| タイトル | 重粒子線の生物効果の細胞周期の影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
加藤, 宝光
× 加藤, 宝光× 加藤 宝光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cell Cycle Takamitsu Kato, Yoshihiro Fujii, Larry Thompson, Akira Fujimori, Ohtsura Niwa, Ryuichi Okayasu \n The fact what cell survival is not dependent on cell cycle with high LET irradiation is strong advantage for the particle cancer therapy compared to conventional x-ray. \nIn order to study the mechanisms of cell cycle independent biological effects in heavy ion exposure, we used DNA repair deficient mutant CHO cell lines, V3.3 (DNA-PKcs) and 51D1 (Rad51D) to analyze cell survival, chromosome aberrations, sister chromatid exchanges. \nThought WT CHO cells lacked cell cycle independent cell killing, non-homologous repair deficient cell and homologous recombination repair deficient cell showed clear cell cycle effect in their survival. \nChromosome analysis revealed DNA-PKcs deficient cells had chromatid-type aberration G1-phase irradiation. High LET irradiation does not induce sister chromatid exchanges in DNA-PKcs deficient cells. \nThose results indicate that complex, dirty DNA damages produced by high LET exposure tend not to be an easy target for homologous recombination repair. And this is the reason why cell survival is not dependent on cell cycle with high LET irradiation |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 放射線影響学会51回 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-11-21 | |||||
| 日付タイプ | Issued | |||||
