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Reduction in Malformations by Low Dose Pre-Irradiation: The Early Beginning of Adaptive Response Story in Fetal Mice
https://repo.qst.go.jp/records/62751
https://repo.qst.go.jp/records/627513fd5a700-aa83-44c4-b440-744aa9c405b0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-29 | |||||
| タイトル | ||||||
| タイトル | Reduction in Malformations by Low Dose Pre-Irradiation: The Early Beginning of Adaptive Response Story in Fetal Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Shang, Yi× Nakajima, Tetsuo× Nenoi, Mitsuru× Hayata, Isamu× 王 冰× 田中 薫× 尚 奕× 中島 徹夫× 根井 充× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation-induced adaptive response is defined as the phenomenon of priming low-dose-induced resistance to subsequent irradiation at higher doses. In the in vitro examinations, diminished detrimental effects such as chromosome aberrations, mutations and cell death are documented in both prokaryotic and eucaryotic cells. In the in vivo investigations, adaptive response is recorded mainly as a rescuing effect resulting in an improved survival. In a series of studies using an in utero model with fetal mice, we demonstrated the existence of adaptive response and characterized the experimental conditions for its successful induction. Radiation induces high incidences of abnormalities and neonatal death in late organogenesis in mice. Gross malformations in limbs, primarily as digital defects, and prenatal fetal death were used as the endpoints. A variety of physical and biological conditions with respect to both irradiation and irradiated subjects are crucial to the induction of adaptive response. In both ICR and C57BL strain fetal mice, priming low dose radiations on gestation day 11 prior to a high dose irradiation on gestation day 12 effectively suppressed malformations in fetal digits and prenatal deaths. The efficient priming dose was mouse strain-related, namely, it was 0.3 Gy for ICR fetal mice, while it was either 0.05 Gy or 0.3 Gy for C57BL fetal mice. Neither 0.05 Gy nor 0.3 Gy could induce an adaptive response in C3H and BALB/c fetal mice. A dose-rate-related effect was observed in delivery of the priming dose to ICR fetal mice, namely, when 0.3 Gy was delivered within two dose-rate ranges, either from 0.18 to 0.98 Gy/min or from 3.5 to 4.6 Gy/min on gestation day 11, it could lead to a reduction of the detrimental effect induced by a challenging dose of 3.5 Gy on gestation day12. Reduction in digital defects was correlated to the decrease in radiation-induced apoptosis in the predigital regions. Induction of adaptive response was dependent on p53 gene status. In C57BL strain mice, adaptive response could not be induced in p53 heterozygous fetal mice under the same conditions as those used in the p53 wild type counterparts. In summary, our findings indicated that radiation-induced adaptive response existed in fetal mice, which manifested as reduction in malformations and prenatal fetal deaths. This adaptive response was due to a complex interplay between dose, dose rate and animal factors such as the strain, developmental stage, and p53 gene status. This work was supported in part by the Budget for New Nuclear Crossover Research from the Ministry of Education, Culture, Sports, Sciences and Technology, Japan. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | NIRS International Symposium on the Effects of Low Dose Radiation | |||||
| 発表年月日 | ||||||
| 日付 | 2008-02-14 | |||||
| 日付タイプ | Issued | |||||
