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重粒子線ならびに化学療法併用における増感効果の放射線生物学的検討
https://repo.qst.go.jp/records/62690
https://repo.qst.go.jp/records/626902d065a0c-6a3c-413d-8b48-a5e590f2ea70
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-03 | |||||
| タイトル | ||||||
| タイトル | 重粒子線ならびに化学療法併用における増感効果の放射線生物学的検討 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
高橋, 健夫
× 高橋, 健夫× 扶川, 武志× 平山, 亮一× 古澤, 佳也× 吉田, 由香里× 鈴木, 義行× 加藤, 真吾× 高橋 健夫× 扶川 武志× 平山 亮一× 古澤 佳也× 吉田 由香里× 鈴木 義行× 加藤 眞吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract: We investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities in sensitivity to high-LET heavy ion beam and in sensitizing effect and the mechanism of cisplatin and etoposide in combination with heavy-ion beam. NMT-1 (wild-type p53 cell) is a parent radiosensitive cell line and NMT-1R (mutant-type p53 cell) is a variant radioresistant cell line. The dose average LET value in the samples was 80 keV/mm. The concentration of chemotherapeutic agents required to reduce colony formation by 50% at 1-hour treatment (IC50 of etoposide) was selected for heavy ion irradiation pretreatment for each cell line. The mechanism of the enhancement effect was investigated by apoptosis and cell cycle and mechanism of DNA repair. The RBE of carbon beam was larger in mutant-type p53 cells than in wild-type p53 cells. Etoposide showed a synergistic effect in combination with carbon beam irradiation in NMT-1R cells. However, there was no enhancement effect in radiosensitive NMT-1 cells. The incidence of apoptosis, the distribution of cell cycle and the ability of DNA repair did not change between carbon beam irradiation alone and the combination of carbon beam irradiation and etoposide od cisplation in both cell lines. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H19年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
